FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2024446407> ?p ?o ?g. }

• W2024446407 endingPage "2002" @default.
• W2024446407 startingPage "1997" @default.
• W2024446407 abstract "As a result of the clinical benefit observed in angina patients treated by transmyocardial revascularization (TMR) with a laser, interest in mechanical TMR has been renewed. Although the injury induced by mechanical TMR is similar to laser TMR, the resultant impact on myocardial contractility is unknown. The purpose of this study was to determine whether mechanical TMR improves ventricular function as compared with laser TMR in chronically ischemic myocardium.After establishing an area of chronic myocardial ischemia, 25 domestic pigs were randomized to treatment by: excimer laser (group I), a hot needle (50 degrees C) (group II), a normothermic needle (group III), an ultrasonic needle (40 KHz) (group IV), or no treatment (group V). All devices create a transmural channel of the same diameter; 22 +/- 1 transmural channels were created in each animal. Regional myocardial contractility was assessed by measuring ventricular wall thickening at rest and with dobutamine stress echocardiography. Six weeks after revascularization, the animals were restudied at rest and with stress. Postsacrifice and histologic analysis of angiogenesis and TMR effects was then assessed.Laser TMR provided significant recovery of ischemic myocardial function. This improvement in contractility after laser TMR was a 75% increase over the baseline function of the ischemic zone (p < 0.01). Mechanical TMR provided no significant improvement in function posttreatment. In fact, TMR achieved with an ultrasonic needle demonstrated a 40% worsening of the contractility versus the pretreatment baseline (p < 0.05). Histologic analysis demonstrated a significant increase in new blood vessels in the ischemic zone after laser TMR, which was not demonstrated for any of the other groups (p < 0.05). Additionally, evaluation of the mechanical TMR channels demonstrated significant scarring, which correlated with the functional results.Using devices to create an injury analogous to the laser, mechanical TMR failed to improve the function of chronically ischemic myocardium. Only laser TMR significantly improved myocardial function." @default.
• W2024446407 created "2016-06-24" @default.
• W2024446407 creator A5000079670 @default.
• W2024446407 creator A5016079400 @default.
• W2024446407 creator A5029462329 @default.
• W2024446407 creator A5043156279 @default.
• W2024446407 creator A5054694606 @default.
• W2024446407 creator A5061547044 @default.
• W2024446407 creator A5067285726 @default.
• W2024446407 creator A5085131808 @default.
• W2024446407 date "2001-12-01" @default.
• W2024446407 modified "2023-10-16" @default.
• W2024446407 title "Functional comparison of transmyocardial revascularization by mechanical and laser means" @default.
• W2024446407 cites W1986928524 @default.
• W2024446407 cites W1996975496 @default.
• W2024446407 cites W1998698950 @default.
• W2024446407 cites W2000600255 @default.
• W2024446407 cites W2011404343 @default.
• W2024446407 cites W2017424364 @default.
• W2024446407 cites W2051987769 @default.
• W2024446407 cites W2052316929 @default.
• W2024446407 cites W2060131789 @default.
• W2024446407 cites W2096737402 @default.
• W2024446407 cites W2103165076 @default.
• W2024446407 cites W2161456369 @default.
• W2024446407 cites W2339007776 @default.
• W2024446407 cites W2464741475 @default.
• W2024446407 cites W54819349 @default.
• W2024446407 doi "https://doi.org/10.1016/s0003-4975(01)03243-x" @default.
• W2024446407 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11789783" @default.
• W2024446407 hasPublicationYear "2001" @default.
• W2024446407 type Work @default.
• W2024446407 sameAs 2024446407 @default.
• W2024446407 citedByCount "26" @default.
• W2024446407 countsByYear W20244464072013 @default.
• W2024446407 countsByYear W20244464072014 @default.
• W2024446407 countsByYear W20244464072015 @default.
• W2024446407 countsByYear W20244464072020 @default.
• W2024446407 crossrefType "journal-article" @default.
• W2024446407 hasAuthorship W2024446407A5000079670 @default.
• W2024446407 hasAuthorship W2024446407A5016079400 @default.
• W2024446407 hasAuthorship W2024446407A5029462329 @default.
• W2024446407 hasAuthorship W2024446407A5043156279 @default.
• W2024446407 hasAuthorship W2024446407A5054694606 @default.
• W2024446407 hasAuthorship W2024446407A5061547044 @default.
• W2024446407 hasAuthorship W2024446407A5067285726 @default.
• W2024446407 hasAuthorship W2024446407A5085131808 @default.
• W2024446407 hasConcept C126322002 @default.
• W2024446407 hasConcept C164705383 @default.
• W2024446407 hasConcept C2778425758 @default.
• W2024446407 hasConcept C39133596 @default.
• W2024446407 hasConcept C42219234 @default.
• W2024446407 hasConcept C500558357 @default.
• W2024446407 hasConcept C541997718 @default.
• W2024446407 hasConcept C71924100 @default.
• W2024446407 hasConceptScore W2024446407C126322002 @default.
• W2024446407 hasConceptScore W2024446407C164705383 @default.
• W2024446407 hasConceptScore W2024446407C2778425758 @default.
• W2024446407 hasConceptScore W2024446407C39133596 @default.
• W2024446407 hasConceptScore W2024446407C42219234 @default.
• W2024446407 hasConceptScore W2024446407C500558357 @default.
• W2024446407 hasConceptScore W2024446407C541997718 @default.
• W2024446407 hasConceptScore W2024446407C71924100 @default.
• W2024446407 hasIssue "6" @default.
• W2024446407 hasLocation W20244464071 @default.
• W2024446407 hasLocation W20244464072 @default.
• W2024446407 hasOpenAccess W2024446407 @default.
• W2024446407 hasPrimaryLocation W20244464071 @default.
• W2024446407 hasRelatedWork W1578364275 @default.
• W2024446407 hasRelatedWork W190250366 @default.
• W2024446407 hasRelatedWork W2065518809 @default.
• W2024446407 hasRelatedWork W2074171729 @default.
• W2024446407 hasRelatedWork W2374518361 @default.
• W2024446407 hasRelatedWork W2379084044 @default.
• W2024446407 hasRelatedWork W2398742161 @default.
• W2024446407 hasRelatedWork W2411149122 @default.
• W2024446407 hasRelatedWork W2433952041 @default.
• W2024446407 hasRelatedWork W4236811438 @default.
• W2024446407 hasVolume "72" @default.
• W2024446407 isParatext "false" @default.
• W2024446407 isRetracted "false" @default.
• W2024446407 magId "2024446407" @default.
• W2024446407 workType "article" @default.