Matches in SemOpenAlex for { <https://semopenalex.org/work/W2024448086> ?p ?o ?g. }
Showing items 1 to 100 of
100
with 100 items per page.
- W2024448086 endingPage "38" @default.
- W2024448086 startingPage "32" @default.
- W2024448086 abstract "The feasibility of using dense gas techniques such as rapid expansion of supercritical solutions (RESS) and aerosol solvent extraction system (ASES) for micronization of pharmaceutical compounds is demonstrated. The chiral nonsteroidal anti-inflammatory racemic ibuprofen is soluble in carbon dioxide at 35°C and pressures above 90 bar. The particle size decreased to less than 2 μm while the degree of crystallinity was slightly decreased when processed by RESS. The dissolution rate of the ibuprofen (a poorly water-soluble compound) was significantly enhanced after processing by RESS. The nonsteroidal anti-inflammatory drug Cu2(indomethacin)4L2(Cu-Indo); (L=dimethylformamide [DMF]), which possessed very low solubility in supercritical CO2, was successfully micronized by ASES at 25°C and 68.9 bar using DMF as the solvent and CO2 as the antisolvent. The concentration of solute dramatically influenced the precipitate characteristics. The particles obtained from the ASES process were changed from bipyramidal to spherical, with particle size less than 5 μm, as the concentration increased from 5 to 100 mg/g. A further increase in solute concentration to 200 mg/g resulted in large porous spheres, between 20 and 50 μ, when processing Cu-Indo by the ASES method. The dissolution rate of the micronized Cu-Indo was significantly higher than the commercial product." @default.
- W2024448086 created "2016-06-24" @default.
- W2024448086 creator A5015794408 @default.
- W2024448086 creator A5018741771 @default.
- W2024448086 creator A5069374909 @default.
- W2024448086 creator A5072475894 @default.
- W2024448086 date "2003-06-01" @default.
- W2024448086 modified "2023-10-17" @default.
- W2024448086 title "Application of dense gas techniques for the production of fine particles" @default.
- W2024448086 cites W1538072395 @default.
- W2024448086 cites W2001737047 @default.
- W2024448086 cites W2027542397 @default.
- W2024448086 cites W2037711639 @default.
- W2024448086 cites W2041286070 @default.
- W2024448086 cites W2047318226 @default.
- W2024448086 cites W2047806739 @default.
- W2024448086 cites W2088666571 @default.
- W2024448086 cites W2113278226 @default.
- W2024448086 cites W2094374191 @default.
- W2024448086 doi "https://doi.org/10.1208/ps050211" @default.
- W2024448086 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2751519" @default.
- W2024448086 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12866938" @default.
- W2024448086 hasPublicationYear "2003" @default.
- W2024448086 type Work @default.
- W2024448086 sameAs 2024448086 @default.
- W2024448086 citedByCount "36" @default.
- W2024448086 countsByYear W20244480862012 @default.
- W2024448086 countsByYear W20244480862014 @default.
- W2024448086 countsByYear W20244480862015 @default.
- W2024448086 countsByYear W20244480862017 @default.
- W2024448086 countsByYear W20244480862018 @default.
- W2024448086 countsByYear W20244480862019 @default.
- W2024448086 countsByYear W20244480862022 @default.
- W2024448086 countsByYear W20244480862023 @default.
- W2024448086 crossrefType "journal-article" @default.
- W2024448086 hasAuthorship W2024448086A5015794408 @default.
- W2024448086 hasAuthorship W2024448086A5018741771 @default.
- W2024448086 hasAuthorship W2024448086A5069374909 @default.
- W2024448086 hasAuthorship W2024448086A5072475894 @default.
- W2024448086 hasBestOaLocation W20244480862 @default.
- W2024448086 hasConcept C118419359 @default.
- W2024448086 hasConcept C127413603 @default.
- W2024448086 hasConcept C134458231 @default.
- W2024448086 hasConcept C13965031 @default.
- W2024448086 hasConcept C147789679 @default.
- W2024448086 hasConcept C155574463 @default.
- W2024448086 hasConcept C178790620 @default.
- W2024448086 hasConcept C185592680 @default.
- W2024448086 hasConcept C187530423 @default.
- W2024448086 hasConcept C192562407 @default.
- W2024448086 hasConcept C2777712214 @default.
- W2024448086 hasConcept C2780471494 @default.
- W2024448086 hasConcept C42360764 @default.
- W2024448086 hasConcept C43617362 @default.
- W2024448086 hasConcept C46275449 @default.
- W2024448086 hasConcept C8010536 @default.
- W2024448086 hasConcept C86178769 @default.
- W2024448086 hasConcept C88380143 @default.
- W2024448086 hasConceptScore W2024448086C118419359 @default.
- W2024448086 hasConceptScore W2024448086C127413603 @default.
- W2024448086 hasConceptScore W2024448086C134458231 @default.
- W2024448086 hasConceptScore W2024448086C13965031 @default.
- W2024448086 hasConceptScore W2024448086C147789679 @default.
- W2024448086 hasConceptScore W2024448086C155574463 @default.
- W2024448086 hasConceptScore W2024448086C178790620 @default.
- W2024448086 hasConceptScore W2024448086C185592680 @default.
- W2024448086 hasConceptScore W2024448086C187530423 @default.
- W2024448086 hasConceptScore W2024448086C192562407 @default.
- W2024448086 hasConceptScore W2024448086C2777712214 @default.
- W2024448086 hasConceptScore W2024448086C2780471494 @default.
- W2024448086 hasConceptScore W2024448086C42360764 @default.
- W2024448086 hasConceptScore W2024448086C43617362 @default.
- W2024448086 hasConceptScore W2024448086C46275449 @default.
- W2024448086 hasConceptScore W2024448086C8010536 @default.
- W2024448086 hasConceptScore W2024448086C86178769 @default.
- W2024448086 hasConceptScore W2024448086C88380143 @default.
- W2024448086 hasIssue "2" @default.
- W2024448086 hasLocation W20244480861 @default.
- W2024448086 hasLocation W20244480862 @default.
- W2024448086 hasLocation W20244480863 @default.
- W2024448086 hasLocation W20244480864 @default.
- W2024448086 hasOpenAccess W2024448086 @default.
- W2024448086 hasPrimaryLocation W20244480861 @default.
- W2024448086 hasRelatedWork W1602047260 @default.
- W2024448086 hasRelatedWork W1974957919 @default.
- W2024448086 hasRelatedWork W2092377262 @default.
- W2024448086 hasRelatedWork W2159452789 @default.
- W2024448086 hasRelatedWork W2358736293 @default.
- W2024448086 hasRelatedWork W2373029394 @default.
- W2024448086 hasRelatedWork W2405826001 @default.
- W2024448086 hasRelatedWork W2587860564 @default.
- W2024448086 hasRelatedWork W2738048673 @default.
- W2024448086 hasRelatedWork W3151492801 @default.
- W2024448086 hasVolume "5" @default.
- W2024448086 isParatext "false" @default.
- W2024448086 isRetracted "false" @default.
- W2024448086 magId "2024448086" @default.
- W2024448086 workType "article" @default.