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- W2024448295 abstract "In order to improve the efficacy and to reduce the side-effects of antiviral drugs in the treatment of chronic hepatitis B, a lysosomotropic approach through covalent linkage of the drugs to appropriate glycoproteins was adopted. Antiviral nucleoside analogs were coupled to asialofetuin and to lactosaminated albumin (L-SA) (two galactosyl-terminating glycoproteins). The conjugates were selectively taken up by liver cells where they released the drugs in a pharmacologically active form. L-SA conjugates showed the advantage of being non-immunogenic when prepared with homologous albumin and injected intravenously. The majority of the experiments reported in this article were performed employing a conjugate of L-SA with ara-AMP, a drug active against hepatitis B virus (HBV). The results of animal studies warranted a 7-day administration of L-HSA-ara-AMP to patients with chronic hepatitis B. Conjugated ara-AMP was shown to inhibit HBV growth at a dose 3–6 times lower than that of the free drug." @default.
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- W2024448295 date "1994-04-01" @default.
- W2024448295 modified "2023-09-25" @default.
- W2024448295 title "Targeting of antiviral drugs to the liver using glycoprotein carriers" @default.
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- W2024448295 doi "https://doi.org/10.1016/0169-409x(94)90005-1" @default.
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