FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2024449023> ?p ?o ?g. }

• W2024449023 endingPage "23" @default.
• W2024449023 startingPage "18" @default.
• W2024449023 abstract "Amino acid polymorphisms of the prion protein gene influence sheep susceptibility to classical and atypical scrapie. Substitutions at codons 136, 154 and 171 play an important role in classical scrapie. Codon 141 leucine to phenylalanine mutation (AFRQ) has been recognized as an increased risk factor for atypical scrapie. In addition a rare allele with lysine at codon 171 (ARK) has been detected in Mediterranean sheep breeds. The presence of ARK poses two problems: the determination of its frequency and its possible interference with genotyping output of routine methods lacking specific detection capacity for ARK. The aim of our work was the development of a routine genotyping method with the capacity to identify ARK and AFRQ in addition to the normally detected alleles and to determine the frequencies of all these alleles in 5 main Italian breeds: Sarda (n = 2494), Bergamasca (n = 2686), Appenninica (n = 297), Comisana (n = 361) and Massese (n = 402). A multiplex primer extension assay targeting the six single nucleotide polymorphisms of interest was developed. Allele frequencies revealed a very low level of ARR in Bergamasca (6.91%) as opposed to the other breeds, very diverse levels of AFRQ ranging from absence in Comisana to 10.70% in Massese and a restricted presence of ARK. This allele has only been detected in Bargamasca with a significant 3.67% and marginally in Appenninica (0.34%). These results underline the need for adequate routine methods for genotyping of breeds with alleles that can interfere with typing of important codons such as the case of ARK for codon 171." @default.
• W2024449023 created "2016-06-24" @default.
• W2024449023 creator A5000067259 @default.
• W2024449023 creator A5004804908 @default.
• W2024449023 creator A5014721350 @default.
• W2024449023 creator A5063039212 @default.
• W2024449023 creator A5065500174 @default.
• W2024449023 creator A5073085116 @default.
• W2024449023 date "2009-05-01" @default.
• W2024449023 modified "2023-09-27" @default.
• W2024449023 title "Prion protein genotypes of Italian sheep breeds with lysine-171 and phenylalanine-141 detection" @default.
• W2024449023 cites W1989071705 @default.
• W2024449023 cites W1994111832 @default.
• W2024449023 cites W2001911362 @default.
• W2024449023 cites W2026539771 @default.
• W2024449023 cites W2028951855 @default.
• W2024449023 cites W2045230080 @default.
• W2024449023 cites W2045291362 @default.
• W2024449023 cites W2047626450 @default.
• W2024449023 cites W2049724475 @default.
• W2024449023 cites W2050025870 @default.
• W2024449023 cites W2052794370 @default.
• W2024449023 cites W2053415431 @default.
• W2024449023 cites W2053492333 @default.
• W2024449023 cites W2057060905 @default.
• W2024449023 cites W2060017096 @default.
• W2024449023 cites W2086186894 @default.
• W2024449023 cites W2090844619 @default.
• W2024449023 cites W2103357056 @default.
• W2024449023 cites W2112574135 @default.
• W2024449023 cites W2113473342 @default.
• W2024449023 cites W2128667083 @default.
• W2024449023 cites W2146246590 @default.
• W2024449023 cites W2155321114 @default.
• W2024449023 cites W340620999 @default.
• W2024449023 doi "https://doi.org/10.1016/j.vetmic.2008.12.012" @default.
• W2024449023 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19157728" @default.
• W2024449023 hasPublicationYear "2009" @default.
• W2024449023 type Work @default.
• W2024449023 sameAs 2024449023 @default.
• W2024449023 citedByCount "13" @default.
• W2024449023 countsByYear W20244490232012 @default.
• W2024449023 countsByYear W20244490232013 @default.
• W2024449023 countsByYear W20244490232014 @default.
• W2024449023 countsByYear W20244490232015 @default.
• W2024449023 countsByYear W20244490232016 @default.
• W2024449023 countsByYear W20244490232018 @default.
• W2024449023 countsByYear W20244490232020 @default.
• W2024449023 crossrefType "journal-article" @default.
• W2024449023 hasAuthorship W2024449023A5000067259 @default.
• W2024449023 hasAuthorship W2024449023A5004804908 @default.
• W2024449023 hasAuthorship W2024449023A5014721350 @default.
• W2024449023 hasAuthorship W2024449023A5063039212 @default.
• W2024449023 hasAuthorship W2024449023A5065500174 @default.
• W2024449023 hasAuthorship W2024449023A5073085116 @default.
• W2024449023 hasBestOaLocation W20244490232 @default.
• W2024449023 hasConcept C104317684 @default.
• W2024449023 hasConcept C135763542 @default.
• W2024449023 hasConcept C142724271 @default.
• W2024449023 hasConcept C153209595 @default.
• W2024449023 hasConcept C153911025 @default.
• W2024449023 hasConcept C180754005 @default.
• W2024449023 hasConcept C2776735649 @default.
• W2024449023 hasConcept C2779134260 @default.
• W2024449023 hasConcept C3019804061 @default.
• W2024449023 hasConcept C31467283 @default.
• W2024449023 hasConcept C37463918 @default.
• W2024449023 hasConcept C54355233 @default.
• W2024449023 hasConcept C71924100 @default.
• W2024449023 hasConcept C86803240 @default.
• W2024449023 hasConceptScore W2024449023C104317684 @default.
• W2024449023 hasConceptScore W2024449023C135763542 @default.
• W2024449023 hasConceptScore W2024449023C142724271 @default.
• W2024449023 hasConceptScore W2024449023C153209595 @default.
• W2024449023 hasConceptScore W2024449023C153911025 @default.
• W2024449023 hasConceptScore W2024449023C180754005 @default.
• W2024449023 hasConceptScore W2024449023C2776735649 @default.
• W2024449023 hasConceptScore W2024449023C2779134260 @default.
• W2024449023 hasConceptScore W2024449023C3019804061 @default.
• W2024449023 hasConceptScore W2024449023C31467283 @default.
• W2024449023 hasConceptScore W2024449023C37463918 @default.
• W2024449023 hasConceptScore W2024449023C54355233 @default.
• W2024449023 hasConceptScore W2024449023C71924100 @default.
• W2024449023 hasConceptScore W2024449023C86803240 @default.
• W2024449023 hasIssue "1-2" @default.
• W2024449023 hasLocation W20244490231 @default.
• W2024449023 hasLocation W20244490232 @default.
• W2024449023 hasLocation W20244490233 @default.
• W2024449023 hasLocation W20244490234 @default.
• W2024449023 hasOpenAccess W2024449023 @default.
• W2024449023 hasPrimaryLocation W20244490231 @default.
• W2024449023 hasRelatedWork W1965247597 @default.
• W2024449023 hasRelatedWork W1969825491 @default.
• W2024449023 hasRelatedWork W2004355765 @default.
• W2024449023 hasRelatedWork W2051135531 @default.
• W2024449023 hasRelatedWork W2089602588 @default.
• W2024449023 hasRelatedWork W2161808406 @default.
• W2024449023 hasRelatedWork W2380126524 @default.

• next