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- W2024450538 abstract "The mechanism by which anti-DNA antibodies cause glomerulonephritis in systemic lupus erythematosus (SLE) has not been fully elucidated. However, not a few recent studies suggest the pivotal role of nucleosomal histones in the binding of immune complexes to the glomerular basement membrane. Some antibodies cross-react with both double-stranded (ds) DNA and nucleosome, but antibodies exclusively specific to the nucleosome have also been described. In lupus model mice, anti-nucleosome antibodies are reported to emerge even before the production of anti-dsDNA antibodies. BK virus T antigen, bacterial DNA, a DNA binding protein nucleobindin and autoreactive helper T cells specific to nucleosome or anti-DNA antibody-derived peptides have been shown to induce or enhance anti-DNA antibody production in normal or lupus-prone animals. These new experimental models are expected to be helpful in the exploration of the true antigen that elicits autoimmune reactions in SLE." @default.
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- W2024450538 date "1998-06-01" @default.
- W2024450538 modified "2023-09-26" @default.
- W2024450538 title "What is the primary antigen in systemic lupus erythematosus?" @default.
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- W2024450538 doi "https://doi.org/10.3109/bf03041333" @default.
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