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- W2024451515 endingPage "37" @default.
- W2024451515 startingPage "27" @default.
- W2024451515 abstract "Five disease-modifying agents are currently approved for long-term treatment of multiple sclerosis (MS), namely three interferon-beta preparations, glatiramer acetate, and mitoxantrone 1 A sixth disease-modifying agent, natalizumab, has been approved for treatment of multiple sclerosis after acceptance of this manuscript. Its pharmacokinetics and pharmacodynamics are not subject of this review. 1A sixth disease-modifying agent, natalizumab, has been approved for treatment of multiple sclerosis after acceptance of this manuscript. Its pharmacokinetics and pharmacodynamics are not subject of this review.. Pharmacokinetics describes the fate of drugs in the human body by studying their absorption, distribution, metabolism and excretion. Pharmacodynamics is dedicated to the mechanisms of action of drugs. The understanding of the pharmacokinetics and pharmacodynamics of the approved disease-modifying agents against MS is of importance as it might contribute to the development of future derivatives with a potentially higher efficacy and a more favourable safety profile. This article reviews data thus far present both on the pharmacokinetics as well as on the putative mechanisms of action of the interferon-betas, glatiramer acetate, and mitoxantrone in the immunopathogenesis of MS." @default.
- W2024451515 created "2016-06-24" @default.
- W2024451515 creator A5030982118 @default.
- W2024451515 creator A5031075667 @default.
- W2024451515 creator A5063615479 @default.
- W2024451515 date "2007-08-01" @default.
- W2024451515 modified "2023-10-10" @default.
- W2024451515 title "Pharmacokinetics and pharmacodynamics of the interferon-betas, glatiramer acetate, and mitoxantrone in multiple sclerosis" @default.
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