Matches in SemOpenAlex for { <https://semopenalex.org/work/W2024452031> ?p ?o ?g. }
Showing items 1 to 97 of
97
with 100 items per page.
- W2024452031 endingPage "168" @default.
- W2024452031 startingPage "157" @default.
- W2024452031 abstract "A series of cyclic monoterpenes has been assessed as skin penetration enhancers towards a model lipophilic drug, oestradiol. In vitro permeation experiments on human epidermal membranes showed that the terpenes varied in their activities; hydrocarbon (e.g., limonene) and cyclic ether (e.g., 1,8-cineole) terpenes were effective accelerants providing approximately 4-fold increases in the permeability coefficient of aqueous oestradiol, whereas alcohols (e.g., carveol), ketones (e.g., menthone) and epoxides (e.g., pinene oxide) were ineffective. The results of this study are compared with terpene activities towards a model hydrophilic drug, 5-fluorouracil. A novel concept, the enhancement index (EI), is introduced to compare differences in terpene activities towards the two permeants; EI provides information as to the partition coefficient and maximum achievable permeation enhancement for a drug, together with a measure of a penetration enhancer's activity towards that drug expressed as a percentage of the maximum effect. This approach permits useful comparisons between the activities of various enhancers towards different drugs." @default.
- W2024452031 created "2016-06-24" @default.
- W2024452031 creator A5022276762 @default.
- W2024452031 creator A5022568201 @default.
- W2024452031 date "1991-08-01" @default.
- W2024452031 modified "2023-10-16" @default.
- W2024452031 title "The enhancement index concept applied to terpene penetration enhancers for human skin and model lipophilic (oestradiol) and hydrophilic (5-fluorouracil) drugs" @default.
- W2024452031 cites W112176633 @default.
- W2024452031 cites W1550353272 @default.
- W2024452031 cites W2003177659 @default.
- W2024452031 cites W2025129627 @default.
- W2024452031 cites W2036424067 @default.
- W2024452031 cites W2050689945 @default.
- W2024452031 cites W2053190965 @default.
- W2024452031 cites W2064066142 @default.
- W2024452031 cites W2081005686 @default.
- W2024452031 cites W2087285580 @default.
- W2024452031 cites W2091247610 @default.
- W2024452031 cites W2111511285 @default.
- W2024452031 cites W2141331305 @default.
- W2024452031 cites W2172187417 @default.
- W2024452031 cites W4317675750 @default.
- W2024452031 doi "https://doi.org/10.1016/0378-5173(91)90232-d" @default.
- W2024452031 hasPublicationYear "1991" @default.
- W2024452031 type Work @default.
- W2024452031 sameAs 2024452031 @default.
- W2024452031 citedByCount "133" @default.
- W2024452031 countsByYear W20244520312012 @default.
- W2024452031 countsByYear W20244520312013 @default.
- W2024452031 countsByYear W20244520312014 @default.
- W2024452031 countsByYear W20244520312015 @default.
- W2024452031 countsByYear W20244520312016 @default.
- W2024452031 countsByYear W20244520312017 @default.
- W2024452031 countsByYear W20244520312018 @default.
- W2024452031 countsByYear W20244520312019 @default.
- W2024452031 countsByYear W20244520312020 @default.
- W2024452031 countsByYear W20244520312021 @default.
- W2024452031 countsByYear W20244520312022 @default.
- W2024452031 countsByYear W20244520312023 @default.
- W2024452031 crossrefType "journal-article" @default.
- W2024452031 hasAuthorship W2024452031A5022276762 @default.
- W2024452031 hasAuthorship W2024452031A5022568201 @default.
- W2024452031 hasConcept C127413603 @default.
- W2024452031 hasConcept C142724271 @default.
- W2024452031 hasConcept C178790620 @default.
- W2024452031 hasConcept C185592680 @default.
- W2024452031 hasConcept C188947578 @default.
- W2024452031 hasConcept C192552737 @default.
- W2024452031 hasConcept C204787440 @default.
- W2024452031 hasConcept C2777964474 @default.
- W2024452031 hasConcept C41625074 @default.
- W2024452031 hasConcept C42475967 @default.
- W2024452031 hasConcept C43617362 @default.
- W2024452031 hasConcept C44937612 @default.
- W2024452031 hasConcept C50670333 @default.
- W2024452031 hasConcept C55493867 @default.
- W2024452031 hasConcept C71924100 @default.
- W2024452031 hasConcept C80107235 @default.
- W2024452031 hasConcept C98274493 @default.
- W2024452031 hasConceptScore W2024452031C127413603 @default.
- W2024452031 hasConceptScore W2024452031C142724271 @default.
- W2024452031 hasConceptScore W2024452031C178790620 @default.
- W2024452031 hasConceptScore W2024452031C185592680 @default.
- W2024452031 hasConceptScore W2024452031C188947578 @default.
- W2024452031 hasConceptScore W2024452031C192552737 @default.
- W2024452031 hasConceptScore W2024452031C204787440 @default.
- W2024452031 hasConceptScore W2024452031C2777964474 @default.
- W2024452031 hasConceptScore W2024452031C41625074 @default.
- W2024452031 hasConceptScore W2024452031C42475967 @default.
- W2024452031 hasConceptScore W2024452031C43617362 @default.
- W2024452031 hasConceptScore W2024452031C44937612 @default.
- W2024452031 hasConceptScore W2024452031C50670333 @default.
- W2024452031 hasConceptScore W2024452031C55493867 @default.
- W2024452031 hasConceptScore W2024452031C71924100 @default.
- W2024452031 hasConceptScore W2024452031C80107235 @default.
- W2024452031 hasConceptScore W2024452031C98274493 @default.
- W2024452031 hasIssue "2-3" @default.
- W2024452031 hasLocation W20244520311 @default.
- W2024452031 hasOpenAccess W2024452031 @default.
- W2024452031 hasPrimaryLocation W20244520311 @default.
- W2024452031 hasRelatedWork W135387682 @default.
- W2024452031 hasRelatedWork W1568007316 @default.
- W2024452031 hasRelatedWork W2023636215 @default.
- W2024452031 hasRelatedWork W2086710708 @default.
- W2024452031 hasRelatedWork W2168240260 @default.
- W2024452031 hasRelatedWork W2338657794 @default.
- W2024452031 hasRelatedWork W2572592638 @default.
- W2024452031 hasRelatedWork W2889107765 @default.
- W2024452031 hasRelatedWork W2909288528 @default.
- W2024452031 hasRelatedWork W3177034545 @default.
- W2024452031 hasVolume "74" @default.
- W2024452031 isParatext "false" @default.
- W2024452031 isRetracted "false" @default.
- W2024452031 magId "2024452031" @default.
- W2024452031 workType "article" @default.