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- W2024452508 abstract "<h2>Abstract</h2> Vascular permeability and the spread of protein-rich fluid has been assessed in experimental injury to the canine thoracic cord. Concussive injuries of 500 and 200 gram-centimetre force (GCF) were produced and the leakage of Evans blue albumin (EBA) studied with fluorescent microscopy. In dogs subjected to a 500 GCF injury, the leakage occurred initially in the central, intermediolateral grey matter, and dorsal horns, immediately after trauma. Veins and venules were primarily affected. Vessels in the outer white matter had EBA in the vessel wall which only rarely spread into the neuropil. Extensive centrifugal and longitudinal spread occurred and EBA reached the pia mater in approximately 6 hr. A similar but less extensive lesion was present in the segments rostral and caudal to the point of trauma. Blood flow was still present in the outer oedematous white matter 6 hr after trauma, as shown by the presence of Thioflavine S in blood vessels. This was injected intravenously immediately prior to death to assess vascular perfusion, The abnormal permeability decreased rapidly after trauma. Six hr after injury leakage of EBA from vessels was minimal. In dogs subjected to a 200 GCF injury the localisation of leakage was similar but decreased in severity." @default.
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- W2024452508 date "1974-07-01" @default.
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- W2024452508 title "Vascular permeability to protein and vasogenic oedema in experimental concussive injuries to the canine spinal cord" @default.
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- W2024452508 doi "https://doi.org/10.1016/0022-510x(74)90002-1" @default.
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