Matches in SemOpenAlex for { <https://semopenalex.org/work/W2024453722> ?p ?o ?g. }
Showing items 1 to 97 of
97
with 100 items per page.
- W2024453722 endingPage "83" @default.
- W2024453722 startingPage "77" @default.
- W2024453722 abstract "The actual time-course of morphine antinociception is shorter than what would be predicted from its elimination kinetics, suggesting the presence of an acute tolerance phenomenon. Since antagonists acting at NMDA subtype of glutamate receptors were repeatedly shown to prolong acute morphine antinociception, acute tolerance may be attributed to hyperactivity of NMDA receptors. The ability of various site-selective NMDA receptor antagonists to affect morphine antinociception (tail-flick test) was assessed in mice 30 and 120 min after acute morphine challenge. Competitive NMDA receptor antagonist 3-(2-carboxypiperazin-4-yl)-1-propenyl-1-phosphonic acid (d-CPPene) (SDZ EAA 494; 0.1–1 mg/kg), low-affinity channel blockers 1-amino-3,5-dimethyl adamantane (memantine) (1–10 mg/kg) and 1-amino-1,3,3,5,5-pentamethyl-cyclohexan hydrochloride (MRZ 2/579) (1–10 mg/kg), glycine site antagonists 5-nitro-6,7-dichloro-1,4-dihydro-2,3-quinoxalinedione (ACEA-1021) (5 or 10 mg/kg) and 8-chloro-4-hydroxy-1-oxo-1,2-dihydropyridaliono(4,5-b)quinoline-5-oxide choline salt (MRZ 2/576) (1–10 mg/kg) were administered intraperitoneally (i.p.) 15 or 30 min prior to the tail-flick test (i.e., interval between injections of morphine and NMDA receptor antagonist was either 0–15 or 90–105 min). ACEA-1021, MRZ 2/576 and to the lesser extent, memantine and MRZ 2/579 enhanced morphine antinociception when tests were conducted 120 but not 30 min post-morphine. d-CPPene potentiated morphine antinociception irrespective of the interval between morphine administration and the tail-flick test. The results suggest that NMDA receptor antagonists may restore analgesic activity of morphine in acutely tolerant mice." @default.
- W2024453722 created "2016-06-24" @default.
- W2024453722 creator A5006025817 @default.
- W2024453722 creator A5013632111 @default.
- W2024453722 creator A5026076703 @default.
- W2024453722 creator A5060706996 @default.
- W2024453722 creator A5061270034 @default.
- W2024453722 date "2000-05-01" @default.
- W2024453722 modified "2023-09-26" @default.
- W2024453722 title "Antinociceptive activity of combination of morphine and NMDA receptor antagonists depends on the inter-injection interval" @default.
- W2024453722 cites W1526412808 @default.
- W2024453722 cites W1800713457 @default.
- W2024453722 cites W1969211143 @default.
- W2024453722 cites W1971903289 @default.
- W2024453722 cites W1973117505 @default.
- W2024453722 cites W1977190191 @default.
- W2024453722 cites W1977885061 @default.
- W2024453722 cites W1978342243 @default.
- W2024453722 cites W1980356075 @default.
- W2024453722 cites W1986569740 @default.
- W2024453722 cites W1990776459 @default.
- W2024453722 cites W1991601559 @default.
- W2024453722 cites W1994196916 @default.
- W2024453722 cites W2001131419 @default.
- W2024453722 cites W2011038828 @default.
- W2024453722 cites W2013886916 @default.
- W2024453722 cites W2014060289 @default.
- W2024453722 cites W2019353612 @default.
- W2024453722 cites W2023243943 @default.
- W2024453722 cites W2030383594 @default.
- W2024453722 cites W2033525233 @default.
- W2024453722 cites W2035385245 @default.
- W2024453722 cites W2036507634 @default.
- W2024453722 cites W2045130274 @default.
- W2024453722 cites W2046160546 @default.
- W2024453722 cites W2073303656 @default.
- W2024453722 cites W2075042374 @default.
- W2024453722 cites W2077361228 @default.
- W2024453722 cites W2088968659 @default.
- W2024453722 cites W2096375567 @default.
- W2024453722 cites W2143046795 @default.
- W2024453722 cites W2163638196 @default.
- W2024453722 doi "https://doi.org/10.1016/s0014-2999(00)00184-9" @default.
- W2024453722 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10822059" @default.
- W2024453722 hasPublicationYear "2000" @default.
- W2024453722 type Work @default.
- W2024453722 sameAs 2024453722 @default.
- W2024453722 citedByCount "29" @default.
- W2024453722 countsByYear W20244537222012 @default.
- W2024453722 countsByYear W20244537222017 @default.
- W2024453722 countsByYear W20244537222020 @default.
- W2024453722 crossrefType "journal-article" @default.
- W2024453722 hasAuthorship W2024453722A5006025817 @default.
- W2024453722 hasAuthorship W2024453722A5013632111 @default.
- W2024453722 hasAuthorship W2024453722A5026076703 @default.
- W2024453722 hasAuthorship W2024453722A5060706996 @default.
- W2024453722 hasAuthorship W2024453722A5061270034 @default.
- W2024453722 hasConcept C170493617 @default.
- W2024453722 hasConcept C185592680 @default.
- W2024453722 hasConcept C2776885963 @default.
- W2024453722 hasConcept C2777389121 @default.
- W2024453722 hasConcept C2779484449 @default.
- W2024453722 hasConcept C55493867 @default.
- W2024453722 hasConcept C67018056 @default.
- W2024453722 hasConcept C71924100 @default.
- W2024453722 hasConcept C98274493 @default.
- W2024453722 hasConceptScore W2024453722C170493617 @default.
- W2024453722 hasConceptScore W2024453722C185592680 @default.
- W2024453722 hasConceptScore W2024453722C2776885963 @default.
- W2024453722 hasConceptScore W2024453722C2777389121 @default.
- W2024453722 hasConceptScore W2024453722C2779484449 @default.
- W2024453722 hasConceptScore W2024453722C55493867 @default.
- W2024453722 hasConceptScore W2024453722C67018056 @default.
- W2024453722 hasConceptScore W2024453722C71924100 @default.
- W2024453722 hasConceptScore W2024453722C98274493 @default.
- W2024453722 hasIssue "2-3" @default.
- W2024453722 hasLocation W20244537221 @default.
- W2024453722 hasLocation W20244537222 @default.
- W2024453722 hasOpenAccess W2024453722 @default.
- W2024453722 hasPrimaryLocation W20244537221 @default.
- W2024453722 hasRelatedWork W1977885061 @default.
- W2024453722 hasRelatedWork W2039071842 @default.
- W2024453722 hasRelatedWork W2051096751 @default.
- W2024453722 hasRelatedWork W2061708898 @default.
- W2024453722 hasRelatedWork W2083333337 @default.
- W2024453722 hasRelatedWork W2108999942 @default.
- W2024453722 hasRelatedWork W2136392664 @default.
- W2024453722 hasRelatedWork W2395497712 @default.
- W2024453722 hasRelatedWork W4250114062 @default.
- W2024453722 hasRelatedWork W2402177125 @default.
- W2024453722 hasVolume "396" @default.
- W2024453722 isParatext "false" @default.
- W2024453722 isRetracted "false" @default.
- W2024453722 magId "2024453722" @default.
- W2024453722 workType "article" @default.