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- W2024453896 abstract "Improvement of EFS of children older than 3 years with high risk medulloblastoma.Between 1993 and 1999, 115 patients (3-18 years, mean 8 years) with high risk medulloblastoma were included. After surgery treatment consisted of chemotherapy ('8in1' and etoposide/carboplatin) before and after craniospinal radiotherapy.Patients were staged using Chang-criteria (PF residue only, M1 and M2/M3) by local investigator as well as by central review panel (82.4% concordance). Chemotherapy was well tolerated without major delays in radiotherapy. With a mean follow up of 81 months (9-119), 5-year EFS was 49.8% and OS 60.1%. In detail according to subgroups EFS was 68.8% for PF residue only, 58.8% for M1 disease and 43.1% for M2/M3.M1 patients are legitimate high risk patients. Survival rates are still very low for high risk medulloblastoma patients and future trials should therefore focus on more intensive (chemotherapy/radiotherapy) treatment." @default.
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- W2024453896 date "2006-11-01" @default.
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- W2024453896 title "Treatment of high risk medulloblastomas in children above the age of 3 years: A SFOP study" @default.
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- W2024453896 doi "https://doi.org/10.1016/j.ejca.2006.02.026" @default.
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