FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2024454400> ?p ?o ?g. }

• W2024454400 endingPage "1540" @default.
• W2024454400 startingPage "1533" @default.
• W2024454400 abstract "The plasma enzyme responsible for primary proteolytic cleavage of growth hormone-releasing hormone (GRH) at the 2-3 amino acid bond was characterized. Native GRH[GRH(1-44)-NH2 and GRH(1-40)-OH], and COOH-terminally shortened fragments [GRH(1-32)-NH2 and GRH(1-29)-NH2] were rapidly cleaved, while GRH(2-32)-NH2 was not degraded at this site. Moreover, degradation to GRH(3-44)-NH2 was unaffected by an aminopeptidase inhibitor, indicating that this metabolite was generated from a single step cleavage by a dipeptidylpeptidase (DPP) rather than sequential aminopeptidase cleavages. Conversion to GRH(3-44)-NH2 was blocked by diprotin A, a DPP type IV (DPP IV) competitive inhibitor. D-Amino acid substitution at either position 1 or 2 also prevented hydrolysis, characteristic of DPP IV. Analysis of endogenous plasma GRH immunoreactivity from a human GRH transgenic pig revealed that the major peak coeluted with GRH(3-44)-NH2. Native GRH exhibited trypsin-like degradation at the 11-12 position but cleavage at the 12-13 site occurred only with GRH(1-32)-NH2 and GRH(1-29)-NH2. Formation of these metabolites was independent of prior DPP IV hydrolysis but was greatly reduced by trypsin inhibitors. Evaluation of plasma stability of potential GRH super analogues, designed to resist degradation by these enzymes, confirmed that GRH degradation in plasma occurs primarily by DPP IV, and to a lesser extent by trypsin-like enzyme(s)." @default.
• W2024454400 created "2016-06-24" @default.
• W2024454400 creator A5050410237 @default.
• W2024454400 creator A5066186978 @default.
• W2024454400 creator A5070268220 @default.
• W2024454400 creator A5075210484 @default.
• W2024454400 date "1989-05-01" @default.
• W2024454400 modified "2023-10-15" @default.
• W2024454400 title "Dipeptidylpeptidase IV and trypsin-like enzymatic degradation of human growth hormone-releasing hormone in plasma." @default.
• W2024454400 cites W1493252203 @default.
• W2024454400 cites W1600900121 @default.
• W2024454400 cites W1829933729 @default.
• W2024454400 cites W1917338879 @default.
• W2024454400 cites W1968667610 @default.
• W2024454400 cites W1971486325 @default.
• W2024454400 cites W1983585570 @default.
• W2024454400 cites W1996018904 @default.
• W2024454400 cites W2001722768 @default.
• W2024454400 cites W2001998235 @default.
• W2024454400 cites W2009163884 @default.
• W2024454400 cites W2016018030 @default.
• W2024454400 cites W2016018886 @default.
• W2024454400 cites W2023138444 @default.
• W2024454400 cites W2036147787 @default.
• W2024454400 cites W2040229070 @default.
• W2024454400 cites W2041492831 @default.
• W2024454400 cites W2047906394 @default.
• W2024454400 cites W2051817117 @default.
• W2024454400 cites W2058832065 @default.
• W2024454400 cites W2063587143 @default.
• W2024454400 cites W2066102305 @default.
• W2024454400 cites W2076735360 @default.
• W2024454400 cites W2080185465 @default.
• W2024454400 cites W2080430256 @default.
• W2024454400 cites W2088890372 @default.
• W2024454400 cites W2155915657 @default.
• W2024454400 cites W2161447126 @default.
• W2024454400 cites W2203310209 @default.
• W2024454400 cites W2413855909 @default.
• W2024454400 cites W2415237372 @default.
• W2024454400 cites W2439341080 @default.
• W2024454400 cites W296938826 @default.
• W2024454400 cites W4290349064 @default.
• W2024454400 cites W45911913 @default.
• W2024454400 cites W85770612 @default.
• W2024454400 doi "https://doi.org/10.1172/jci114049" @default.
• W2024454400 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/303858" @default.
• W2024454400 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/2565342" @default.
• W2024454400 hasPublicationYear "1989" @default.
• W2024454400 type Work @default.
• W2024454400 sameAs 2024454400 @default.
• W2024454400 citedByCount "167" @default.
• W2024454400 countsByYear W20244544002012 @default.
• W2024454400 countsByYear W20244544002013 @default.
• W2024454400 countsByYear W20244544002014 @default.
• W2024454400 countsByYear W20244544002016 @default.
• W2024454400 countsByYear W20244544002017 @default.
• W2024454400 countsByYear W20244544002019 @default.
• W2024454400 countsByYear W20244544002020 @default.
• W2024454400 countsByYear W20244544002021 @default.
• W2024454400 countsByYear W20244544002022 @default.
• W2024454400 countsByYear W20244544002023 @default.
• W2024454400 crossrefType "journal-article" @default.
• W2024454400 hasAuthorship W2024454400A5050410237 @default.
• W2024454400 hasAuthorship W2024454400A5066186978 @default.
• W2024454400 hasAuthorship W2024454400A5070268220 @default.
• W2024454400 hasAuthorship W2024454400A5075210484 @default.
• W2024454400 hasBestOaLocation W20244544001 @default.
• W2024454400 hasConcept C126322002 @default.
• W2024454400 hasConcept C134018914 @default.
• W2024454400 hasConcept C181199279 @default.
• W2024454400 hasConcept C185592680 @default.
• W2024454400 hasConcept C2776351012 @default.
• W2024454400 hasConcept C2780340462 @default.
• W2024454400 hasConcept C2781307694 @default.
• W2024454400 hasConcept C55493867 @default.
• W2024454400 hasConcept C71924100 @default.
• W2024454400 hasConcept C86803240 @default.
• W2024454400 hasConceptScore W2024454400C126322002 @default.
• W2024454400 hasConceptScore W2024454400C134018914 @default.
• W2024454400 hasConceptScore W2024454400C181199279 @default.
• W2024454400 hasConceptScore W2024454400C185592680 @default.
• W2024454400 hasConceptScore W2024454400C2776351012 @default.
• W2024454400 hasConceptScore W2024454400C2780340462 @default.
• W2024454400 hasConceptScore W2024454400C2781307694 @default.
• W2024454400 hasConceptScore W2024454400C55493867 @default.
• W2024454400 hasConceptScore W2024454400C71924100 @default.
• W2024454400 hasConceptScore W2024454400C86803240 @default.
• W2024454400 hasIssue "5" @default.
• W2024454400 hasLocation W20244544001 @default.
• W2024454400 hasLocation W20244544002 @default.
• W2024454400 hasLocation W20244544003 @default.
• W2024454400 hasLocation W20244544004 @default.
• W2024454400 hasOpenAccess W2024454400 @default.
• W2024454400 hasPrimaryLocation W20244544001 @default.
• W2024454400 hasRelatedWork W2002688036 @default.
• W2024454400 hasRelatedWork W2004766780 @default.
• W2024454400 hasRelatedWork W2032767708 @default.

• next