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• W2024455827 startingPage "I22" @default.
• W2024455827 abstract "Nearly half of the proteins in the complement system serve in regulation. Control at the central step of C3 activation is provided by an orchestrated interplay of membrane and plasma regulators. A model system employing Chinese hamster ovary (CHO) cells transfected with human regulators was employed to assist in making functional comparisons. Also, in this experimental setup, the pathway and magnitude of complement activation can be varied while monitoring C4b/C3b deposition and cleavage as well as cytotoxicity. This review describes lessons learned and the application of this model for functionally characterizing mutations in regulators associated with atypical hemolytic uremic syndrome." @default.
• W2024455827 created "2016-06-24" @default.
• W2024455827 creator A5008491017 @default.
• W2024455827 creator A5010301180 @default.
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• W2024455827 date "2008-12-01" @default.
• W2024455827 modified "2023-09-25" @default.
• W2024455827 title "Inhibiting complement activation on cells at the step of C3 cleavage" @default.
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• W2024455827 doi "https://doi.org/10.1016/j.vaccine.2008.11.001" @default.
• W2024455827 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2768381" @default.
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• W2024455827 hasPublicationYear "2008" @default.
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