FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2024455851> ?p ?o ?g. }

• W2024455851 endingPage "399" @default.
• W2024455851 startingPage "392" @default.
• W2024455851 abstract "Potent inhibitors of purine nucleoside phosphorylase (PNP) are expected to act as selective agents against T-cell tumours. Five compounds with guanine, three with hypoxanthine, and five with 9-deazaguanine, all connected by a linker with difluoromethylene phosphonic acid, were studied on their inhibitory potential against human and calf PNPs. Antiproliferative activity of these analogues against lymphocytes as well as lymphoma and leukaemia cells has been also investigated. All tested compounds act as multisubstrate analogue inhibitors of PNP with the apparent inhibition constants in the range 5–100 nm, and also show a slight antiproliferative activity. Analogues with 9-deazaguanine aglycone have better anti-leukaemic and anti-lymphoma activities compared to the guanine and hypoxanthine analogues, and applied in the concentration of 100 μm, caused a statistically significant decrease in the cell viability in all human leukaemia and lymphoma cells used. Despite the high PNP inhibitory potential of tested analogues, no differences were observed between the effects on the growth of tumour cells sensible to the inhibition of PNP, such as human adult T-cell leukaemia and lymphoma cells, and other investigated cells. Obtained poor effects on cell proliferation could be explained probably by a poor ability of tested compounds to penetrate cell membranes." @default.
• W2024455851 created "2016-06-24" @default.
• W2024455851 creator A5007494352 @default.
• W2024455851 creator A5010231714 @default.
• W2024455851 creator A5020210972 @default.
• W2024455851 creator A5027593014 @default.
• W2024455851 creator A5039685784 @default.
• W2024455851 creator A5075876459 @default.
• W2024455851 creator A5086917677 @default.
• W2024455851 date "2010-04-01" @default.
• W2024455851 modified "2023-10-17" @default.
• W2024455851 title "Antiproliferative Activity of Purine Nucleoside Phosphorylase Multisubstrate Analogue Inhibitors Containing Difluoromethylene Phosphonic Acid against Leukaemia and Lymphoma Cells" @default.
• W2024455851 cites W1512072225 @default.
• W2024455851 cites W1966830283 @default.
• W2024455851 cites W1976980965 @default.
• W2024455851 cites W1977663662 @default.
• W2024455851 cites W1980313028 @default.
• W2024455851 cites W1980569536 @default.
• W2024455851 cites W1993789171 @default.
• W2024455851 cites W2003217261 @default.
• W2024455851 cites W2006732267 @default.
• W2024455851 cites W2012373472 @default.
• W2024455851 cites W2012848071 @default.
• W2024455851 cites W2017138631 @default.
• W2024455851 cites W2017918262 @default.
• W2024455851 cites W2018075506 @default.
• W2024455851 cites W2032117722 @default.
• W2024455851 cites W2037637555 @default.
• W2024455851 cites W2041505150 @default.
• W2024455851 cites W2044568888 @default.
• W2024455851 cites W2046491432 @default.
• W2024455851 cites W2072754530 @default.
• W2024455851 cites W2085394517 @default.
• W2024455851 cites W2100383422 @default.
• W2024455851 cites W2105767107 @default.
• W2024455851 cites W2110861536 @default.
• W2024455851 cites W2116579030 @default.
• W2024455851 cites W2129986214 @default.
• W2024455851 cites W2133484973 @default.
• W2024455851 cites W2142060917 @default.
• W2024455851 cites W2160055463 @default.
• W2024455851 cites W2179945677 @default.
• W2024455851 doi "https://doi.org/10.1111/j.1747-0285.2009.00939.x" @default.
• W2024455851 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20102369" @default.
• W2024455851 hasPublicationYear "2010" @default.
• W2024455851 type Work @default.
• W2024455851 sameAs 2024455851 @default.
• W2024455851 citedByCount "7" @default.
• W2024455851 countsByYear W20244558512013 @default.
• W2024455851 countsByYear W20244558512020 @default.
• W2024455851 countsByYear W20244558512021 @default.
• W2024455851 countsByYear W20244558512022 @default.
• W2024455851 countsByYear W20244558512023 @default.
• W2024455851 crossrefType "journal-article" @default.
• W2024455851 hasAuthorship W2024455851A5007494352 @default.
• W2024455851 hasAuthorship W2024455851A5010231714 @default.
• W2024455851 hasAuthorship W2024455851A5020210972 @default.
• W2024455851 hasAuthorship W2024455851A5027593014 @default.
• W2024455851 hasAuthorship W2024455851A5039685784 @default.
• W2024455851 hasAuthorship W2024455851A5075876459 @default.
• W2024455851 hasAuthorship W2024455851A5086917677 @default.
• W2024455851 hasBestOaLocation W20244558511 @default.
• W2024455851 hasConcept C104317684 @default.
• W2024455851 hasConcept C109316439 @default.
• W2024455851 hasConcept C181199279 @default.
• W2024455851 hasConcept C185592680 @default.
• W2024455851 hasConcept C202751555 @default.
• W2024455851 hasConcept C2776476023 @default.
• W2024455851 hasConcept C2776543447 @default.
• W2024455851 hasConcept C2778301229 @default.
• W2024455851 hasConcept C2781116151 @default.
• W2024455851 hasConcept C512185932 @default.
• W2024455851 hasConcept C55493867 @default.
• W2024455851 hasConcept C62112901 @default.
• W2024455851 hasConcept C71615608 @default.
• W2024455851 hasConceptScore W2024455851C104317684 @default.
• W2024455851 hasConceptScore W2024455851C109316439 @default.
• W2024455851 hasConceptScore W2024455851C181199279 @default.
• W2024455851 hasConceptScore W2024455851C185592680 @default.
• W2024455851 hasConceptScore W2024455851C202751555 @default.
• W2024455851 hasConceptScore W2024455851C2776476023 @default.
• W2024455851 hasConceptScore W2024455851C2776543447 @default.
• W2024455851 hasConceptScore W2024455851C2778301229 @default.
• W2024455851 hasConceptScore W2024455851C2781116151 @default.
• W2024455851 hasConceptScore W2024455851C512185932 @default.
• W2024455851 hasConceptScore W2024455851C55493867 @default.
• W2024455851 hasConceptScore W2024455851C62112901 @default.
• W2024455851 hasConceptScore W2024455851C71615608 @default.
• W2024455851 hasIssue "4" @default.
• W2024455851 hasLocation W20244558511 @default.
• W2024455851 hasLocation W20244558512 @default.
• W2024455851 hasOpenAccess W2024455851 @default.
• W2024455851 hasPrimaryLocation W20244558511 @default.
• W2024455851 hasRelatedWork W1504841080 @default.
• W2024455851 hasRelatedWork W1621443637 @default.
• W2024455851 hasRelatedWork W1630992622 @default.
• W2024455851 hasRelatedWork W1639745312 @default.
• W2024455851 hasRelatedWork W1985654998 @default.

• next