FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2024455909> ?p ?o ?g. }

• W2024455909 endingPage "e0116582" @default.
• W2024455909 startingPage "e0116582" @default.
• W2024455909 abstract "Type 1 diabetes (T1D) is caused by autoimmune disease that leads to the destruction of pancreatic β-cells. Transplantation of cadaveric pancreatic organs or pancreatic islets can restore normal physiology. However, there is a chronic shortage of cadaveric organs, limiting the treatment of the majority of patients on the pancreas transplantation waiting list. Here, we hypothesized that human iPS cells can be directly differentiated into insulin producing cells (IPCs) capable of secreting insulin. Using a series of pancreatic growth factors, we successfully generated iPS cells derived IPCs. Furthermore, to investigate the capability of these cells to secrete insulin in vivo, the differentiated cells were transplanted under the kidney capsules of diabetic immunodeficient mice. Serum glucose levels gradually declined to either normal or near normal levels over 150 days, suggesting that the IPCs were secreting insulin. In addition, using MRI, a 3D organoid appeared as a white patch on the transplanted kidneys but not on the control kidneys. These organoids showed neo-vascularization and stained positive for insulin and glucagon. All together, these data show that a pancreatic organ can be created in vivo providing evidence that iPS cells might be a novel option for the treatment of T1D." @default.
• W2024455909 created "2016-06-24" @default.
• W2024455909 creator A5011650333 @default.
• W2024455909 creator A5028314308 @default.
• W2024455909 creator A5032808557 @default.
• W2024455909 creator A5045136684 @default.
• W2024455909 creator A5051210233 @default.
• W2024455909 creator A5089814381 @default.
• W2024455909 date "2015-01-28" @default.
• W2024455909 modified "2023-10-07" @default.
• W2024455909 title "Human iPS Cell-Derived Insulin Producing Cells Form Vascularized Organoids under the Kidney Capsules of Diabetic Mice" @default.
• W2024455909 cites W1510928501 @default.
• W2024455909 cites W1973453325 @default.
• W2024455909 cites W1979001502 @default.
• W2024455909 cites W1993222615 @default.
• W2024455909 cites W2011644642 @default.
• W2024455909 cites W2019665736 @default.
• W2024455909 cites W2026739290 @default.
• W2024455909 cites W2032058920 @default.
• W2024455909 cites W2032472678 @default.
• W2024455909 cites W2034293734 @default.
• W2024455909 cites W2041178941 @default.
• W2024455909 cites W2044025778 @default.
• W2024455909 cites W2048056915 @default.
• W2024455909 cites W2054361177 @default.
• W2024455909 cites W2074439077 @default.
• W2024455909 cites W2077083016 @default.
• W2024455909 cites W2081363988 @default.
• W2024455909 cites W2081482262 @default.
• W2024455909 cites W2083462941 @default.
• W2024455909 cites W2120322647 @default.
• W2024455909 cites W2125987139 @default.
• W2024455909 cites W2127259226 @default.
• W2024455909 cites W2132046208 @default.
• W2024455909 cites W2138977668 @default.
• W2024455909 cites W2147402097 @default.
• W2024455909 cites W2148890861 @default.
• W2024455909 cites W2167185768 @default.
• W2024455909 cites W2170560537 @default.
• W2024455909 cites W2325216586 @default.
• W2024455909 doi "https://doi.org/10.1371/journal.pone.0116582" @default.
• W2024455909 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4309616" @default.
• W2024455909 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25629318" @default.
• W2024455909 hasPublicationYear "2015" @default.
• W2024455909 type Work @default.
• W2024455909 sameAs 2024455909 @default.
• W2024455909 citedByCount "47" @default.
• W2024455909 countsByYear W20244559092015 @default.
• W2024455909 countsByYear W20244559092016 @default.
• W2024455909 countsByYear W20244559092017 @default.
• W2024455909 countsByYear W20244559092018 @default.
• W2024455909 countsByYear W20244559092019 @default.
• W2024455909 countsByYear W20244559092020 @default.
• W2024455909 countsByYear W20244559092021 @default.
• W2024455909 countsByYear W20244559092022 @default.
• W2024455909 countsByYear W20244559092023 @default.
• W2024455909 crossrefType "journal-article" @default.
• W2024455909 hasAuthorship W2024455909A5011650333 @default.
• W2024455909 hasAuthorship W2024455909A5028314308 @default.
• W2024455909 hasAuthorship W2024455909A5032808557 @default.
• W2024455909 hasAuthorship W2024455909A5045136684 @default.
• W2024455909 hasAuthorship W2024455909A5051210233 @default.
• W2024455909 hasAuthorship W2024455909A5089814381 @default.
• W2024455909 hasBestOaLocation W20244559091 @default.
• W2024455909 hasConcept C126322002 @default.
• W2024455909 hasConcept C134018914 @default.
• W2024455909 hasConcept C150903083 @default.
• W2024455909 hasConcept C165220095 @default.
• W2024455909 hasConcept C201750760 @default.
• W2024455909 hasConcept C207001950 @default.
• W2024455909 hasConcept C26291073 @default.
• W2024455909 hasConcept C2778764654 @default.
• W2024455909 hasConcept C2778881546 @default.
• W2024455909 hasConcept C2779306644 @default.
• W2024455909 hasConcept C2779855799 @default.
• W2024455909 hasConcept C2780091579 @default.
• W2024455909 hasConcept C28328180 @default.
• W2024455909 hasConcept C2911091166 @default.
• W2024455909 hasConcept C31695470 @default.
• W2024455909 hasConcept C555293320 @default.
• W2024455909 hasConcept C71924100 @default.
• W2024455909 hasConcept C86803240 @default.
• W2024455909 hasConcept C95444343 @default.
• W2024455909 hasConceptScore W2024455909C126322002 @default.
• W2024455909 hasConceptScore W2024455909C134018914 @default.
• W2024455909 hasConceptScore W2024455909C150903083 @default.
• W2024455909 hasConceptScore W2024455909C165220095 @default.
• W2024455909 hasConceptScore W2024455909C201750760 @default.
• W2024455909 hasConceptScore W2024455909C207001950 @default.
• W2024455909 hasConceptScore W2024455909C26291073 @default.
• W2024455909 hasConceptScore W2024455909C2778764654 @default.
• W2024455909 hasConceptScore W2024455909C2778881546 @default.
• W2024455909 hasConceptScore W2024455909C2779306644 @default.
• W2024455909 hasConceptScore W2024455909C2779855799 @default.
• W2024455909 hasConceptScore W2024455909C2780091579 @default.
• W2024455909 hasConceptScore W2024455909C28328180 @default.
• W2024455909 hasConceptScore W2024455909C2911091166 @default.
• W2024455909 hasConceptScore W2024455909C31695470 @default.

• next