Matches in SemOpenAlex for { <https://semopenalex.org/work/W2024457110> ?p ?o ?g. }
Showing items 1 to 72 of
72
with 100 items per page.
- W2024457110 abstract "The pharmacokinetics of recainam, an anti-arrhythmic drug, were compared in mice, rats, rabbits, dogs, rhesus monkeys, and man. Bioavailability was virtually complete in monkeys and dogs, 67 per cent in man and 51 per cent in rats. Non-linear kinetics between the oral and i.v. dose in rabbits precluded estimation of bioavailability. Linear plasma dose proportionality occurred in dogs between 6 and 60 mg kg-1 oral doses and rhesus monkeys between 1 and 15 mg kg-1 i.v. doses. A greater than proportional increase in the plasma AUC of recainam occurred between oral doses ranging from 54-208 mg kg-1 in mice, 25-110 mg kg-1 in rats, and 50-100 mg kg-1 in rabbits. In human subjects, the AUC/unit dose was linear between 400 and 800 mg. The terminal elimination t1/2 of recainam ranged from 1-5h in laboratory animals and man. The plasma Cmax and AUC of recainam were virtually identical after single or multiple (21 day) oral doses in dogs. After an i.v. dose, plasma clearance of recainam (l kg-1 .h) was 4.9-5.2 in rats and rabbits and 0.4-1.9 in dogs, rhesus monkeys, and man. The steady state volume of distribution was 2-5 times larger than the total body water of laboratory animals and man. Recainam was very poorly bound (10-45 per cent) to the serum proteins of rodents, rabbits, dogs, rhesus monkeys and man. In rhesus monkeys and man, recainam accounted for 10 per cent and 70 per cent, respectively, of the plasma radioactivity at 6 h post-dose. The pharmacokinetic profile of recainam in dogs most closely resembled that of man." @default.
- W2024457110 created "2016-06-24" @default.
- W2024457110 creator A5002998232 @default.
- W2024457110 creator A5004540049 @default.
- W2024457110 creator A5017082193 @default.
- W2024457110 creator A5020756072 @default.
- W2024457110 creator A5062828842 @default.
- W2024457110 creator A5087927269 @default.
- W2024457110 date "1990-07-01" @default.
- W2024457110 modified "2023-09-26" @default.
- W2024457110 title "Species differences in the pharmacokinetics of recainam, a new anti-arrhythmic drug" @default.
- W2024457110 cites W1501075349 @default.
- W2024457110 cites W2001457377 @default.
- W2024457110 cites W2008022714 @default.
- W2024457110 cites W2023447830 @default.
- W2024457110 cites W2041887632 @default.
- W2024457110 cites W205765438 @default.
- W2024457110 cites W2066756597 @default.
- W2024457110 cites W2068058568 @default.
- W2024457110 cites W2086057391 @default.
- W2024457110 cites W2090879932 @default.
- W2024457110 cites W2400066329 @default.
- W2024457110 doi "https://doi.org/10.1002/bdd.2510110508" @default.
- W2024457110 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/2207297" @default.
- W2024457110 hasPublicationYear "1990" @default.
- W2024457110 type Work @default.
- W2024457110 sameAs 2024457110 @default.
- W2024457110 citedByCount "11" @default.
- W2024457110 countsByYear W20244571102013 @default.
- W2024457110 crossrefType "journal-article" @default.
- W2024457110 hasAuthorship W2024457110A5002998232 @default.
- W2024457110 hasAuthorship W2024457110A5004540049 @default.
- W2024457110 hasAuthorship W2024457110A5017082193 @default.
- W2024457110 hasAuthorship W2024457110A5020756072 @default.
- W2024457110 hasAuthorship W2024457110A5062828842 @default.
- W2024457110 hasAuthorship W2024457110A5087927269 @default.
- W2024457110 hasConcept C112705442 @default.
- W2024457110 hasConcept C126322002 @default.
- W2024457110 hasConcept C139254425 @default.
- W2024457110 hasConcept C181389837 @default.
- W2024457110 hasConcept C185592680 @default.
- W2024457110 hasConcept C22979827 @default.
- W2024457110 hasConcept C2777056448 @default.
- W2024457110 hasConcept C71924100 @default.
- W2024457110 hasConcept C98274493 @default.
- W2024457110 hasConceptScore W2024457110C112705442 @default.
- W2024457110 hasConceptScore W2024457110C126322002 @default.
- W2024457110 hasConceptScore W2024457110C139254425 @default.
- W2024457110 hasConceptScore W2024457110C181389837 @default.
- W2024457110 hasConceptScore W2024457110C185592680 @default.
- W2024457110 hasConceptScore W2024457110C22979827 @default.
- W2024457110 hasConceptScore W2024457110C2777056448 @default.
- W2024457110 hasConceptScore W2024457110C71924100 @default.
- W2024457110 hasConceptScore W2024457110C98274493 @default.
- W2024457110 hasLocation W20244571101 @default.
- W2024457110 hasLocation W20244571102 @default.
- W2024457110 hasOpenAccess W2024457110 @default.
- W2024457110 hasPrimaryLocation W20244571101 @default.
- W2024457110 hasRelatedWork W1489015605 @default.
- W2024457110 hasRelatedWork W1980852908 @default.
- W2024457110 hasRelatedWork W2013413873 @default.
- W2024457110 hasRelatedWork W2020497888 @default.
- W2024457110 hasRelatedWork W2023697648 @default.
- W2024457110 hasRelatedWork W2026309482 @default.
- W2024457110 hasRelatedWork W2049291913 @default.
- W2024457110 hasRelatedWork W2049802977 @default.
- W2024457110 hasRelatedWork W2086460393 @default.
- W2024457110 hasRelatedWork W2370600970 @default.
- W2024457110 isParatext "false" @default.
- W2024457110 isRetracted "false" @default.
- W2024457110 magId "2024457110" @default.
- W2024457110 workType "article" @default.