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- W2024457903 abstract "Important discoveries came forth when human cell lines were used for screening drugs and other chems. This investigation dets. the toxicity profiles of neoplastic drugs utilizing human lymphocytes from peripheral blood samples of healthy non-smoking donors and the blood samples of cancer patients suffering from acute myeloid leukemia (AML) were collected. The order of toxicities (LC50) using MTT assay was found to be as follows; Cisplatin > Carboplatin > Cyclophosphamide > 5-FU > Vincristine. The values were calcd. using statistical anal. The MTT assay is now widely adopted by researchers and industry, as it is a rapid Spectrophotometric method for detg. cell viability in cells. The changes induced by individual drugs could be unique to each compd. which might reflect in genotoxicity, hence utilizing the Single Cell Gel Electrophoresis (SCGE) assay, genotoxicity of the drugs was detd. as comet tails of DNA damages. It was found that the values obtained were significant (p<0.04) and showed that the damage was highest in cisplatin as compared to other drugs. The order of toxicity in comet assay was similar to that of MTT assay. It is therefore concluded that the two assays could be used simultaneously to det. the toxic properties of the drugs on human cells and can be compared to cancer cells. [on SciFinder(R)]" @default.
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- W2024457903 date "2006-06-15" @default.
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- W2024457903 title "Application of Human Lymphocytes for Evaluating Toxicity of Anti-Cancer Drugs" @default.
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