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- W2024457918 abstract "In Brief Complement factor H (CFH) has been implicated in the predisposition to advanced forms of age-related macular degeneration (AMD). The purpose of this review is to highlight recent discoveries implicating single nucleotide polymorphisms on 1q32, 6p21, and 10q26 in the risk for development of AMD. In addition, the central role of CFH in the complement cascade and its role in the inflammatory hypothesis for AMD are reviewed. The role of complement factor H and other inflammatory mediators in the pathogenesis of age-related macular degeneration across many different populations is reviewed." @default.
- W2024457918 created "2016-06-24" @default.
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- W2024457918 date "2007-03-01" @default.
- W2024457918 modified "2023-10-15" @default.
- W2024457918 title "ROLE OF GENETIC FACTORS AND INFLAMMATION IN AGE-RELATED MACULAR DEGENERATION" @default.
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- W2024457918 doi "https://doi.org/10.1097/iae.0b013e31802e3e9b" @default.
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