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• W2024462308 abstract "Objective: Testing of serum for protein patterns to monitor progression of suspected to definite chronic pancreatitis (CP). Methods: Serum samples of CP patients and healthy volunteers were fractionated on anion exchange columns and analyzed by surface-enhanced laser desorption/ionization-time-of-flight mass spectrometry to elucidate CP-related protein alterations and to identify biomarkers for this disease. Potential biomarkers were purified and identified by mass spectrometry. Results: In total, 258 protein peaks were found that discriminated between the 2 groups. Analysis revealed 28 most prominent peaks on immobilized metal affinity capture coupled with Cu and CM10 protein chips, covering the m/z range between 3.3 and 33.3 kd. Performing multivariate pattern analysis, the best pattern model was obtained using fraction 6 on immobilized metal affinity capture coupled with Cu arrays with a sensitivity of 96% and a specificity of 84%. Using a combination of matrix-assisted laser desorption-ionization-time-of-flight mass spectrometry and immunodepletion, we identified 14-m/z peaks. The proteins were found to be significantly decreased in CP serum and were identified as retinol-binding protein, serum amyloid-α, apolipoprotein A-II (Apo A-II), Apo C-I, Apo C-II, Apo C-III, and transthyretin and truncated forms thereof. Conclusions: Distinct protein profile differences exist between normal and CP serum and reflect the metabolic and inflammatory condition in CP patients. The identified protein panel may eventually serve as a diagnostic marker set for CP." @default.
• W2024462308 created "2016-06-24" @default.
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• W2024462308 date "2007-11-01" @default.
• W2024462308 modified "2023-09-26" @default.
• W2024462308 title "Protein Expression Profiling Reveals Distinctive Changes in Serum Proteins Associated With Chronic Pancreatitis" @default.
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• W2024462308 doi "https://doi.org/10.1097/mpa.0b013e3180cac723" @default.
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