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- W2024462414 abstract "(1) The impermeant polyanion suramin inhibits the (Na+ - K+)-activated ATPase in broken membrane preparations. Suramin does not affect Na+ or K+ transport in intact red cells or resealed red cell ghosts when present in the incubation medium, but appears to inhibit the Na+ pump in ghosts resealed with suramin inside. Other ATP-requiring enzymes are also inhibited by suramin with similar potency (50% inhibition at 10−5-10−4 M) suggesting an interaction with the substrate site of the enzyme. (2) K+-activated p-nitrophenylphosphatase activity and [3H]ouabain binding are also inhibited by suramin. (3) The inhibition by suramin is reversed by washing the membranes. (4) It is concluded that suramin inhibits the Na+-K+ transport system through interactions with the intracellular part of the pump. (5) The potential usefulness of suramin as a pump inhibitor and the possibility of modifying its structure to yield fluorescent derivatives are discussed." @default.
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- W2024462414 date "1973-08-01" @default.
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- W2024462414 title "Suramin: A potent ATPase inhibitor which acts on the inside surface of the sodium pump" @default.
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- W2024462414 doi "https://doi.org/10.1016/0005-2736(73)90119-3" @default.
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