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Matches in SemOpenAlex for { <https://semopenalex.org/work/W2024462903> ?p ?o ?g. }

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• W2024462903 abstract "Endothelial lipase (EL) activity has been implicated in HDL metabolism and in atherosclerotic plaque development; inhibitors are proposed to be efficacious in the treatment of dyslipidemia related cardiovascular disease. We describe here the discovery of a novel class of anthranilic acids EL inhibitors. XEN445 (compound 13) was identified as a potent and selective EL inhibitor, that showed good ADME and PK properties, and demonstrated in vivo efficacy in raising plasma HDLc concentrations in mice." @default.
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• W2024462903 date "2013-12-01" @default.
• W2024462903 modified "2023-10-01" @default.
• W2024462903 title "Discovery of XEN445: A potent and selective endothelial lipase inhibitor raises plasma HDL-cholesterol concentration in mice" @default.
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• W2024462903 doi "https://doi.org/10.1016/j.bmc.2013.10.023" @default.
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