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- W2024465865 abstract "Our group of studies investigated the action of butane-2,3-dione thiosemicarbazone oxime against the testicular damage caused by cadmium chloride (CdCl2) in mice. Mice received a single injection of CdCl2 (5 mg/kg, intraperitoneally) and, after thirty minutes, the oxime (10 mg/kg, subcutaneously) was administered. Twenty four hours after the last administration, the animals were killed by cervical dislocation and the testes and serum were removed for analysis. The parameters determined were δ-aminolevulinate dehydratase (δ-ALA-D), myeloperoxidase (MPO), glutathione-S-transferase (GST) and glutathione peroxidase (GPx) activities. The levels of thiobarbituric acid-reactive substances (TBARS), nonprotein thiols (NPSH), ascorbic acid, cadmium and testosterone were also determined. In addition, histological analysis and cytokines quantification (IL-1, IL-6, IL-10, TNF-α and IFN-γ) were performed. Our results demonstrated that the oxime was effective in restoring the inhibition in δ-ALA-D activity induced by CdCl2. The activation of MPO and increase in IL-1, IL-6, TNF-α and IFN-γ levels induced by CdCl2 were also reduced by oxime. IL-10, which was reduced by cadmium, was restored by oxime administration. In addition, the oxime was effective in restoring the increase in TBARS levels and the reduction on NPSH levels induced by CdCl2. Our results demonstrated that oxime was effective in containing the histological alterations induced by CdCl2. In addition, oxime was able to increase the testosterone levels, reduced by cadmium exposure. In conclusion, the oxime tested was effective in reducing the testicular damage induced by CdCl2 in mice. The beneficial effects of this oxime are related to its antioxidant and anti-inflammatory action." @default.
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- W2024465865 date "2012-01-01" @default.
- W2024465865 modified "2023-10-03" @default.
- W2024465865 title "Effects of butane-2,3-dione thiosemicarbazone oxime on testicular damage induced by cadmium in mice" @default.
- W2024465865 cites W129370812 @default.
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- W2024465865 cites W182540526 @default.
- W2024465865 cites W1965834241 @default.
- W2024465865 cites W1972646235 @default.
- W2024465865 cites W1973624081 @default.
- W2024465865 cites W1975220274 @default.
- W2024465865 cites W1983066436 @default.
- W2024465865 cites W1983310681 @default.
- W2024465865 cites W1984571847 @default.
- W2024465865 cites W1986752439 @default.
- W2024465865 cites W1988397659 @default.
- W2024465865 cites W1989953524 @default.
- W2024465865 cites W1990229605 @default.
- W2024465865 cites W1991535520 @default.
- W2024465865 cites W1991626506 @default.
- W2024465865 cites W1993112159 @default.
- W2024465865 cites W1993747925 @default.
- W2024465865 cites W1996960515 @default.
- W2024465865 cites W1999180950 @default.
- W2024465865 cites W1999292652 @default.
- W2024465865 cites W2003051737 @default.
- W2024465865 cites W2006370393 @default.
- W2024465865 cites W2007235707 @default.
- W2024465865 cites W2009414893 @default.
- W2024465865 cites W2010820975 @default.
- W2024465865 cites W2016537201 @default.
- W2024465865 cites W2018994512 @default.
- W2024465865 cites W2024432240 @default.
- W2024465865 cites W2031623505 @default.
- W2024465865 cites W2035554117 @default.
- W2024465865 cites W2036301368 @default.
- W2024465865 cites W2038600241 @default.
- W2024465865 cites W2041750631 @default.
- W2024465865 cites W2042868758 @default.
- W2024465865 cites W2044213031 @default.
- W2024465865 cites W2049407206 @default.
- W2024465865 cites W2049730127 @default.
- W2024465865 cites W2057426634 @default.
- W2024465865 cites W2059336697 @default.
- W2024465865 cites W2059829735 @default.
- W2024465865 cites W2060169326 @default.
- W2024465865 cites W2060330834 @default.
- W2024465865 cites W2061643619 @default.
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- W2024465865 cites W2075635449 @default.
- W2024465865 cites W2077240758 @default.
- W2024465865 cites W2081745487 @default.
- W2024465865 cites W2082863092 @default.
- W2024465865 cites W2089636719 @default.
- W2024465865 cites W2105090342 @default.
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- W2024465865 cites W2151093371 @default.
- W2024465865 cites W2165179719 @default.
- W2024465865 cites W2170481593 @default.
- W2024465865 cites W2400418602 @default.
- W2024465865 cites W2770221822 @default.
- W2024465865 cites W2998412404 @default.
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- W2024465865 doi "https://doi.org/10.2131/jts.37.899" @default.
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