Matches in SemOpenAlex for { <https://semopenalex.org/work/W2024467620> ?p ?o ?g. }
- W2024467620 abstract "Introduction: Tourette syndrome (TS) is a neuropsychiatric disorder with the core phenomenon of tics, whose origin and temporal pattern are unclear. We investigated the When and Where of tic generation and resting state networks (RSNs) via functional magnetic resonance imaging (fMRI). Methods: Tic-related activity and the underlying resting state networks in adult TS were studied within one fMRI session. Participants were instructed to lie in the scanner and to let tics occur freely. Tic onset times, as determined by video-observance were used as regressors and added to preceding time-bins of one second duration each to detect prior activation. RSN were identified by independent component analysis (ICA) and correlated to disease severity by the means of dual regression. Results: Two seconds before a tic, the supplementary motor area (SMA), ventral primary motor cortex, primary sensorimotor cortex and parietal operculum exhibited activation; one second before a tic, the anterior cingulate, putamen, insula, amygdala, cerebellum and the extrastriatal-visual cortex exhibited activation; with tic-onset, the thalamus, central operculum, primary motor and somatosensory cortices exhibited activation. Analysis of resting state data resulted in 21 components including the so-called default-mode network. Network strength in those regions in SMA of two premotor ICA maps that were also active prior to tic occurrence, correlated significantly with disease severity according to the Yale Global Tic Severity Scale (YGTTS) scores. Discussion: We demonstrate that the temporal pattern of tic generation follows the cortico-striato-thalamo-cortical circuit, and that cortical structures precede subcortical activation. The analysis of spontaneous fluctuations highlights the role of cortical premotor structures. Our study corroborates the notion of TS as a network disorder in which abnormal resting state network activity might contribute to the generation of tics in SMA." @default.
- W2024467620 created "2016-06-24" @default.
- W2024467620 creator A5000102709 @default.
- W2024467620 creator A5023834438 @default.
- W2024467620 creator A5036486668 @default.
- W2024467620 creator A5046907765 @default.
- W2024467620 creator A5052251830 @default.
- W2024467620 creator A5058335367 @default.
- W2024467620 creator A5071643772 @default.
- W2024467620 creator A5077384471 @default.
- W2024467620 date "2014-05-28" @default.
- W2024467620 modified "2023-10-18" @default.
- W2024467620 title "Imaging the where and when of tic generation and resting state networks in adult Tourette patients" @default.
- W2024467620 cites W1596515083 @default.
- W2024467620 cites W1694363227 @default.
- W2024467620 cites W1780332285 @default.
- W2024467620 cites W1902361870 @default.
- W2024467620 cites W1904647953 @default.
- W2024467620 cites W1949714316 @default.
- W2024467620 cites W1968770448 @default.
- W2024467620 cites W1970375293 @default.
- W2024467620 cites W1970562208 @default.
- W2024467620 cites W1971498617 @default.
- W2024467620 cites W1977284696 @default.
- W2024467620 cites W1977761644 @default.
- W2024467620 cites W1979072695 @default.
- W2024467620 cites W1984145644 @default.
- W2024467620 cites W1986794301 @default.
- W2024467620 cites W1987777830 @default.
- W2024467620 cites W1998247306 @default.
- W2024467620 cites W1999292711 @default.
- W2024467620 cites W2002923643 @default.
- W2024467620 cites W2003689507 @default.
- W2024467620 cites W2005160506 @default.
- W2024467620 cites W2009329597 @default.
- W2024467620 cites W2009494091 @default.
- W2024467620 cites W2011282508 @default.
- W2024467620 cites W2019101336 @default.
- W2024467620 cites W2019665425 @default.
- W2024467620 cites W2020084640 @default.
- W2024467620 cites W2020924439 @default.
- W2024467620 cites W2021181097 @default.
- W2024467620 cites W2028214718 @default.
- W2024467620 cites W2033671805 @default.
- W2024467620 cites W2033904073 @default.
- W2024467620 cites W2037267027 @default.
- W2024467620 cites W2040891874 @default.
- W2024467620 cites W2041325253 @default.
- W2024467620 cites W2045880676 @default.
- W2024467620 cites W2050430957 @default.
- W2024467620 cites W2052579703 @default.
- W2024467620 cites W2055313631 @default.
- W2024467620 cites W2055718946 @default.
- W2024467620 cites W2059017974 @default.
- W2024467620 cites W2060128323 @default.
- W2024467620 cites W2067659395 @default.
- W2024467620 cites W2069431273 @default.
- W2024467620 cites W2071937933 @default.
- W2024467620 cites W2078152479 @default.
- W2024467620 cites W2079450984 @default.
- W2024467620 cites W2079594336 @default.
- W2024467620 cites W2084789425 @default.
- W2024467620 cites W2089131745 @default.
- W2024467620 cites W2091178362 @default.
- W2024467620 cites W2091795027 @default.
- W2024467620 cites W2101249624 @default.
- W2024467620 cites W2102932646 @default.
- W2024467620 cites W2106218602 @default.
- W2024467620 cites W2107360535 @default.
- W2024467620 cites W2108646822 @default.
- W2024467620 cites W2109107192 @default.
- W2024467620 cites W2109541060 @default.
- W2024467620 cites W2112852801 @default.
- W2024467620 cites W2117381358 @default.
- W2024467620 cites W2117621792 @default.
- W2024467620 cites W2123649732 @default.
- W2024467620 cites W2126165064 @default.
- W2024467620 cites W2131807485 @default.
- W2024467620 cites W2131822484 @default.
- W2024467620 cites W2132301123 @default.
- W2024467620 cites W2133679625 @default.
- W2024467620 cites W2133903921 @default.
- W2024467620 cites W2136435696 @default.
- W2024467620 cites W2138038505 @default.
- W2024467620 cites W2138790588 @default.
- W2024467620 cites W2142823391 @default.
- W2024467620 cites W2143285014 @default.
- W2024467620 cites W2143951357 @default.
- W2024467620 cites W2150139344 @default.
- W2024467620 cites W2151601667 @default.
- W2024467620 cites W2157805084 @default.
- W2024467620 cites W2158240393 @default.
- W2024467620 cites W2162010696 @default.
- W2024467620 cites W2165673024 @default.
- W2024467620 cites W2165793012 @default.
- W2024467620 cites W2169102115 @default.
- W2024467620 cites W2725457659 @default.
- W2024467620 cites W4206446960 @default.
- W2024467620 cites W4245448017 @default.
- W2024467620 cites W4254838286 @default.