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- W2024467838 abstract "The activity of trivalent and pentavalent antimonials, Undecano-amidine, Pentamidine, Fungizone and four isothiouronium derivatives was studied on the culture form of leishmania obtained from different types of cutaneous infections. Except in the case of Fungizone, the activity of the same drug against the various organism tested (Leishmania brasiliensis, Leishmania leproide, Leishmania tropica, Leishmania enriettii) was of the same order. The alkyl-monoamidine and the therapeutically effective diamidine did not differ in vitro. The isothiouronium derivatives, characterized by a wide activity spectrum, possess in vitro antileishmanial activity of the same magnitude as the diamidines.The complex SbIII compound Stibophen, in contrast to Tartar emetic, was ineffective in vitro. Neither Stibophen nor Tartar emetic inactivated succinic dehydrogenase in the flagellate, though in certain cases a reduction of enzymatic activity was noticed in organisms immobilized by the latter drug. This is attributed to a nonspecific mechanism. Fungizone applied in multiples of the leishmanicidal dose, which did not abolish however completely flagellar movements, had no effect on enzymatic activity.Mapharsen, reported to inhibit succinic dehydrogenase, had no action on enzymatic activity in the flagellate. Dodecylisocyanide methyl chloride abolished motility at the same time and concentration that it inhibited succinic dehydrogenase activity in L. enriettii." @default.
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- W2024467838 date "1998-08-01" @default.
- W2024467838 modified "2023-10-14" @default.
- W2024467838 title "Response to antileishmanial chemotherapy in leishmania-HIV co-infected patients is influenced by the HIV viral load levels before initiation of therapy" @default.
- W2024467838 doi "https://doi.org/10.1016/s1383-5769(98)81155-0" @default.
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