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• W2024473771 abstract "<b>Background:</b> Adiponectin is a protein secreted by adipose cells that improves insulin sensitivity and possesses antiatherogenic properties. In this study, we investigated the relationship between adiponectin levels and ischemic stroke subtype. <b>Methods:</b> Using clinical, imaging, and laboratory data, 231 consecutive patients admitted to a university medical center over a 2-year period with acute cerebral infarcts were categorized into four subtypes: intracranial atherosclerosis (n = 67), extracranial atherosclerosis (n = 61), small arterial occlusion (n = 63), and cardioembolic (n = 40). Clinical features, risk factors including the presence of metabolic syndrome, and levels of s-adiponectin were compared between groups. <b>Results:</b> Patients with more severe metabolic abnormalities were more likely to have lower s-adiponectin levels (<i>p</i> = 0.002). S-adiponectin levels differed by stroke subtype: highest in the cardioembolic group and lowest in the intracranial atherosclerosis group (8.42 ± 5.07 vs 5.60 ± 2.79 μg/mL, <i>p</i> = 0.01). Extracranial atherosclerosis (6.45 ± 4.10 μg/mL) and small arterial occlusion (6.07 ± 3.44 μg/mL) groups were intermediate. Patients with advanced intracranial atherosclerosis (≥1 additional lesion outside the symptomatic arterial territory) had lower s-adiponectin levels than those with isolated intracranial atherosclerosis (4.95 ± 2.63 vs 6.13 ± 2.84 μg/mL, <i>p</i> = 0.003). In multiple regression analysis, s-adiponectin levels, but not metabolic syndrome, were independently associated with intracranial atherosclerosis. <b>Conclusions:</b> Symptomatic intracranial atherosclerosis is associated with lower s-adiponectin levels vs other ischemic stroke subtypes." @default.
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• W2024473771 date "2007-05-29" @default.
• W2024473771 modified "2023-10-18" @default.
• W2024473771 title "Adiponectin levels in patients with intracranial atherosclerosis" @default.
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• W2024473771 doi "https://doi.org/10.1212/01.wnl.0000263186.20988.9f" @default.
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