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- W2024476012 abstract "<b>Background:</b> The association of pemphigus vulgaris with the HLA serotypes, DR4 and DRw6, and with the DQ-β chain alleles, DQwl and DQw3, suggests that there is a genetic predisposition to this disease. However, familial cases of pemphigus vulgaris are exceedingly rare. <b>Objective:</b> We studied two siblings with pemphigus vulgaris and three unaffected family members to determine whether an HLA allele was associated with the development of pernphigus vulgaris in this family. <b>Methods:</b> We utilized restriction fragment length polymorphism methods using the HLA-ADβ1, HLA-DQα, and HLA-DWβ1 genes as cDNA probes. <b>Results:</b> We found that the affected siblings share the haplotype HLA-DR4 and the DQw.3.2 allele. <b>Conclusion:</b> Our findings of gene sharing among siblings with pemphigus vulgaris lend support to previous studies of unrelated Caucasian patients, which implicated DQw3 allele polymorphisms in conferring susceptibility to pemphigus." @default.
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- W2024476012 date "1992-08-01" @default.
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- W2024476012 title "Pemphigus vulgaris in siblings: HLA-DR4 and HLA-DQw3 and susceptibility to pemphigus" @default.
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- W2024476012 doi "https://doi.org/10.1016/0190-9622(92)70168-f" @default.
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