Matches in SemOpenAlex for { <https://semopenalex.org/work/W2024476792> ?p ?o ?g. }
Showing items 1 to 100 of
100
with 100 items per page.
- W2024476792 endingPage "294" @default.
- W2024476792 startingPage "286" @default.
- W2024476792 abstract "Objective. To evaluate the effectiveness of a uniform single-center treatment protocol composed of high-dose methotrexate (MTX) and oral corticosteroids in a pediatric localized scleroderma (LS) cohort. Methods. Thirty-six patients with LS were recruited. Patients with active disease, defined as erythematous lesions and/or new lesions, or expansion of existing lesions, were started on oral prednisone 2 mg/kg/day (maximum 60 mg/day) and subcutaneous (SC) MTX at 1 mg/kg/week (maximum 25 mg/week). Prednisone was tapered and kept at 0.25 mg/kg/day for 12 months. MTX SC was continued for 24 months, and then switched to oral administration to complete 36 months of therapy. Modified LS Skin Severity Index (mLoSSI) and the physician global assessment of disease activity (PGA-A) were used as outcome measures. Results. Twenty-five patients with LS were female with a median age at onset of 7.86 years [interquartile range (IQR) 4.63–11.91]. Median disease duration from onset until start of this treatment regimen was 19.2 months (IQR 8.96–35.35). Median duration of followup was 36.40 months (IQR 29.39–45.36). All patients demonstrated significant improvement in mLoSSI at median 1.77 months (IQR 0.76–2.37, 95% CI 1.54, 2.01). PGA-A followed the same trend. No significant adverse reactions or flares were observed during therapy. Conclusion. This single-center LS treatment protocol was effective and well tolerated. Clinical outcome in LS is affected by dose and route of administration of immunosuppressive regimens. Daily tapering dose of corticosteroids and parenteral MTX were effective in controlling LS activity without significant adverse reaction. This regimen should be considered as one of the therapies for LS clinical trials." @default.
- W2024476792 created "2016-06-24" @default.
- W2024476792 creator A5020176584 @default.
- W2024476792 creator A5032533439 @default.
- W2024476792 date "2012-01-15" @default.
- W2024476792 modified "2023-10-16" @default.
- W2024476792 title "Methotrexate and Corticosteroids in the Treatment of Localized Scleroderma: A Standardized Prospective Longitudinal Single-center Study" @default.
- W2024476792 cites W1968900245 @default.
- W2024476792 cites W1971294942 @default.
- W2024476792 cites W1984640981 @default.
- W2024476792 cites W1994597518 @default.
- W2024476792 cites W2016418227 @default.
- W2024476792 cites W2016759483 @default.
- W2024476792 cites W2019833987 @default.
- W2024476792 cites W2022133180 @default.
- W2024476792 cites W2048674643 @default.
- W2024476792 cites W2049244261 @default.
- W2024476792 cites W2061263498 @default.
- W2024476792 cites W2089773409 @default.
- W2024476792 cites W2112617461 @default.
- W2024476792 cites W2113869393 @default.
- W2024476792 cites W2122058541 @default.
- W2024476792 cites W2129989036 @default.
- W2024476792 cites W2133262418 @default.
- W2024476792 cites W2135698289 @default.
- W2024476792 cites W2149183272 @default.
- W2024476792 cites W2149389714 @default.
- W2024476792 cites W2158781546 @default.
- W2024476792 cites W2161913883 @default.
- W2024476792 doi "https://doi.org/10.3899/jrheum.110210" @default.
- W2024476792 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3744892" @default.
- W2024476792 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22247357" @default.
- W2024476792 hasPublicationYear "2012" @default.
- W2024476792 type Work @default.
- W2024476792 sameAs 2024476792 @default.
- W2024476792 citedByCount "79" @default.
- W2024476792 countsByYear W20244767922012 @default.
- W2024476792 countsByYear W20244767922013 @default.
- W2024476792 countsByYear W20244767922014 @default.
- W2024476792 countsByYear W20244767922015 @default.
- W2024476792 countsByYear W20244767922016 @default.
- W2024476792 countsByYear W20244767922017 @default.
- W2024476792 countsByYear W20244767922018 @default.
- W2024476792 countsByYear W20244767922019 @default.
- W2024476792 countsByYear W20244767922020 @default.
- W2024476792 countsByYear W20244767922021 @default.
- W2024476792 countsByYear W20244767922022 @default.
- W2024476792 countsByYear W20244767922023 @default.
- W2024476792 crossrefType "journal-article" @default.
- W2024476792 hasAuthorship W2024476792A5020176584 @default.
- W2024476792 hasAuthorship W2024476792A5032533439 @default.
- W2024476792 hasBestOaLocation W20244767921 @default.
- W2024476792 hasConcept C119060515 @default.
- W2024476792 hasConcept C126322002 @default.
- W2024476792 hasConcept C141071460 @default.
- W2024476792 hasConcept C188816634 @default.
- W2024476792 hasConcept C197934379 @default.
- W2024476792 hasConcept C2776804153 @default.
- W2024476792 hasConcept C2778720950 @default.
- W2024476792 hasConcept C2780073493 @default.
- W2024476792 hasConcept C2781059491 @default.
- W2024476792 hasConcept C2781413609 @default.
- W2024476792 hasConcept C71924100 @default.
- W2024476792 hasConcept C90924648 @default.
- W2024476792 hasConceptScore W2024476792C119060515 @default.
- W2024476792 hasConceptScore W2024476792C126322002 @default.
- W2024476792 hasConceptScore W2024476792C141071460 @default.
- W2024476792 hasConceptScore W2024476792C188816634 @default.
- W2024476792 hasConceptScore W2024476792C197934379 @default.
- W2024476792 hasConceptScore W2024476792C2776804153 @default.
- W2024476792 hasConceptScore W2024476792C2778720950 @default.
- W2024476792 hasConceptScore W2024476792C2780073493 @default.
- W2024476792 hasConceptScore W2024476792C2781059491 @default.
- W2024476792 hasConceptScore W2024476792C2781413609 @default.
- W2024476792 hasConceptScore W2024476792C71924100 @default.
- W2024476792 hasConceptScore W2024476792C90924648 @default.
- W2024476792 hasIssue "2" @default.
- W2024476792 hasLocation W20244767921 @default.
- W2024476792 hasLocation W20244767922 @default.
- W2024476792 hasLocation W20244767923 @default.
- W2024476792 hasLocation W20244767924 @default.
- W2024476792 hasOpenAccess W2024476792 @default.
- W2024476792 hasPrimaryLocation W20244767921 @default.
- W2024476792 hasRelatedWork W117041192 @default.
- W2024476792 hasRelatedWork W1966445690 @default.
- W2024476792 hasRelatedWork W2004589503 @default.
- W2024476792 hasRelatedWork W2024476792 @default.
- W2024476792 hasRelatedWork W2322750583 @default.
- W2024476792 hasRelatedWork W2356066682 @default.
- W2024476792 hasRelatedWork W2411194530 @default.
- W2024476792 hasRelatedWork W2412931861 @default.
- W2024476792 hasRelatedWork W2463161475 @default.
- W2024476792 hasRelatedWork W2410654613 @default.
- W2024476792 hasVolume "39" @default.
- W2024476792 isParatext "false" @default.
- W2024476792 isRetracted "false" @default.
- W2024476792 magId "2024476792" @default.
- W2024476792 workType "article" @default.