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- W2024478237 abstract "ObjectivePercutaneous epididymal sperm extraction (PESA) and testicular sperm extraction (TESE) are acceptable sperm retrieval techniques for men with obstructive azoospermia (OA). In men with OA, epidydimal sperm quality (motility) can be highly variable and it is unclear whether this factor may impact on reproductive outcomes. We sought to examine and compare the In vitro fertilization/ICSI (IVF/ICSI) reproductive outcomes in men with OA in whom epididymal sperm (with poor or good motility) or testicular sperm was used.DesignRetrospective evaluation of 29 consecutive first-attempt cycles of IVF/ICSI using surgically retrieved sperm from men with OA.Materials and methodsPESA was attempted in all cases and ICSI was performed with either fresh or frozen-thawed epididymal spermatozoa. TESE was performed in cases where no motile sperm were recovered from either the fresh or frozen-thawed PESA samples. Only fresh testicular sperm were used in ICSI cycles. We examined and compared the reproductive outcomes of three groups: (A) PESA-ICSI cycles (n = 8) with “poor” quality sperm (≤2% motility), (B) PESA-ICSI cycles (n = 12) with “good” quality sperm (>2% motility) and (C) TESE-ICSI cycles (n = 9).ResultsSpermatozoa were recovered in all 29 cycles. Male diagnosis (e.g. vasectomy, absent vas deferens), female age, day 3 serum FSH level, response to ovarian stimulation, fertilization rate and number of embryos transferred were not significantly different between the 3 groups. The ongoing pregnancy rates for groups A, B and C were 38%, 67% and 89%, respectively. The difference in ongoing clinical pregnancy rate between groups A (‘poor’ PESA) and C (TESE) was statistically significant (P<0.05).ConclusionsOur data indicate that PESA-ICSI outcomes may be influenced by epididymal sperm quality (motility). Taken together, the data suggest that in men with OA, TESE may be a better option than PESA when epididymal sperm motility is very poor. ObjectivePercutaneous epididymal sperm extraction (PESA) and testicular sperm extraction (TESE) are acceptable sperm retrieval techniques for men with obstructive azoospermia (OA). In men with OA, epidydimal sperm quality (motility) can be highly variable and it is unclear whether this factor may impact on reproductive outcomes. We sought to examine and compare the In vitro fertilization/ICSI (IVF/ICSI) reproductive outcomes in men with OA in whom epididymal sperm (with poor or good motility) or testicular sperm was used. Percutaneous epididymal sperm extraction (PESA) and testicular sperm extraction (TESE) are acceptable sperm retrieval techniques for men with obstructive azoospermia (OA). In men with OA, epidydimal sperm quality (motility) can be highly variable and it is unclear whether this factor may impact on reproductive outcomes. We sought to examine and compare the In vitro fertilization/ICSI (IVF/ICSI) reproductive outcomes in men with OA in whom epididymal sperm (with poor or good motility) or testicular sperm was used. DesignRetrospective evaluation of 29 consecutive first-attempt cycles of IVF/ICSI using surgically retrieved sperm from men with OA. Retrospective evaluation of 29 consecutive first-attempt cycles of IVF/ICSI using surgically retrieved sperm from men with OA. Materials and methodsPESA was attempted in all cases and ICSI was performed with either fresh or frozen-thawed epididymal spermatozoa. TESE was performed in cases where no motile sperm were recovered from either the fresh or frozen-thawed PESA samples. Only fresh testicular sperm were used in ICSI cycles. We examined and compared the reproductive outcomes of three groups: (A) PESA-ICSI cycles (n = 8) with “poor” quality sperm (≤2% motility), (B) PESA-ICSI cycles (n = 12) with “good” quality sperm (>2% motility) and (C) TESE-ICSI cycles (n = 9). PESA was attempted in all cases and ICSI was performed with either fresh or frozen-thawed epididymal spermatozoa. TESE was performed in cases where no motile sperm were recovered from either the fresh or frozen-thawed PESA samples. Only fresh testicular sperm were used in ICSI cycles. We examined and compared the reproductive outcomes of three groups: (A) PESA-ICSI cycles (n = 8) with “poor” quality sperm (≤2% motility), (B) PESA-ICSI cycles (n = 12) with “good” quality sperm (>2% motility) and (C) TESE-ICSI cycles (n = 9). ResultsSpermatozoa were recovered in all 29 cycles. Male diagnosis (e.g. vasectomy, absent vas deferens), female age, day 3 serum FSH level, response to ovarian stimulation, fertilization rate and number of embryos transferred were not significantly different between the 3 groups. The ongoing pregnancy rates for groups A, B and C were 38%, 67% and 89%, respectively. The difference in ongoing clinical pregnancy rate between groups A (‘poor’ PESA) and C (TESE) was statistically significant (P<0.05). Spermatozoa were recovered in all 29 cycles. Male diagnosis (e.g. vasectomy, absent vas deferens), female age, day 3 serum FSH level, response to ovarian stimulation, fertilization rate and number of embryos transferred were not significantly different between the 3 groups. The ongoing pregnancy rates for groups A, B and C were 38%, 67% and 89%, respectively. The difference in ongoing clinical pregnancy rate between groups A (‘poor’ PESA) and C (TESE) was statistically significant (P<0.05). ConclusionsOur data indicate that PESA-ICSI outcomes may be influenced by epididymal sperm quality (motility). Taken together, the data suggest that in men with OA, TESE may be a better option than PESA when epididymal sperm motility is very poor. Our data indicate that PESA-ICSI outcomes may be influenced by epididymal sperm quality (motility). Taken together, the data suggest that in men with OA, TESE may be a better option than PESA when epididymal sperm motility is very poor." @default.
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- W2024478237 title "Epididymal sperm quality may influence intracytoplasmic sperm injection (ICSI) outcomes: role of testicular sperm extraction (TESE) in men with obstructive azoospermia" @default.
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