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- W2024480000 abstract "Abstract Mistlero C was shown to be non-genotoxic in a series of genotoxicity tests, including a bacterial reverse mutation test and a combined in vivo mammalian erythrocyte micronucleus test. In a bacterial reverse mutation assay, no significant increases in the number of revertant colonies, compared to the negative control, was detected in 5,000 ㎍/plate of Mistlero C. In addition, with Mistlero C, no changes were shown in the number of micronucleated polychromatic erythrocytes (MNPCE) among 2,000 polychromatic erythrocytes compared to the negative control. Mistlero C was administered orally in rats to investigate acute toxicity. The LD 50 values in rats were above 2,000 ㎎/㎏. In a repeated dose, 13-week, oral toxicity study conducted in rats, no compound-related adverse effects were shown at doses of Mistlero C of up to 1,000 ㎎/㎏ body weight/day. The results of these studies support the safe use of Mistlero C in food for human consumption.Key words: mistletoe, genetic toxicity, micronucleus test, bacterial reverse mutation assay, toxicity" @default.
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- W2024480000 date "2013-09-30" @default.
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- W2024480000 title "Safety Evaluation of Korean Mistletoe Extract" @default.
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- W2024480000 doi "https://doi.org/10.9799/ksfan.2013.26.3.383" @default.
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