FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2024480425> ?p ?o ?g. }

• W2024480425 endingPage "e57732" @default.
• W2024480425 startingPage "e57732" @default.
• W2024480425 abstract "It is now well established that the developing embryo is very sensitive to oxidative stress, which is a contributing factor to pregnancy-related disorders. However, little is known about the effects of reactive oxygen species (ROS) on the embryonic cardiovascular system due to a lack of appropriate ROS control method in the placenta. In this study, a small molecule called 2,2-azobis(2-amidinopropane) dihydrochloride (AAPH), a free radicals generator, was used to study the effects of oxidative stress on the cardiovascular system during chick embryo development. When nine-day-old (stage HH 35) chick embryos were treated with different concentrations of AAPH inside the air chamber, it was established that the LD50 value for AAPH was 10 µmol/egg. At this concentration, AAPH was found to significantly reduce the density of blood vessel plexus that was developed in the chorioallantoic membrane (CAM) of HH 35 chick embryos. Impacts of AAPH on younger embryos were also examined and discovered that it inhibited the development of vascular plexus on yolk sac in HH 18 embryos. AAPH also dramatically repressed the development of blood islands in HH 3+ embryos. These results implied that AAPH-induced oxidative stress could impair the whole developmental processes associated with vasculogenesis and angiogenesis. Furthermore, we observed heart enlargement in the HH 40 embryo following AAPH treatment, where the left ventricle and interventricular septum were found to be thickened in a dose-dependent manner due to myocardiac cell hypertrophy. In conclusion, oxidative stress, induced by AAPH, could lead to damage of the cardiovascular system in the developing chick embryo. The current study also provided a new developmental model, as an alternative for animal and cell models, for testing small molecules and drugs that have anti-oxidative activities." @default.
• W2024480425 created "2016-06-24" @default.
• W2024480425 creator A5015391354 @default.
• W2024480425 creator A5024792434 @default.
• W2024480425 creator A5029014004 @default.
• W2024480425 creator A5040189982 @default.
• W2024480425 creator A5046014971 @default.
• W2024480425 creator A5055129897 @default.
• W2024480425 creator A5055960115 @default.
• W2024480425 creator A5065047234 @default.
• W2024480425 creator A5076357748 @default.
• W2024480425 creator A5088519518 @default.
• W2024480425 date "2013-03-01" @default.
• W2024480425 modified "2023-10-09" @default.
• W2024480425 title "A New Oxidative Stress Model, 2,2-Azobis(2-Amidinopropane) Dihydrochloride Induces Cardiovascular Damages in Chicken Embryo" @default.
• W2024480425 cites W101093177 @default.
• W2024480425 cites W1862226811 @default.
• W2024480425 cites W1971383450 @default.
• W2024480425 cites W1974684319 @default.
• W2024480425 cites W1975781920 @default.
• W2024480425 cites W1981780292 @default.
• W2024480425 cites W2002679487 @default.
• W2024480425 cites W2021066472 @default.
• W2024480425 cites W2026157576 @default.
• W2024480425 cites W2026197044 @default.
• W2024480425 cites W2037880480 @default.
• W2024480425 cites W2039108603 @default.
• W2024480425 cites W2064738940 @default.
• W2024480425 cites W2065896485 @default.
• W2024480425 cites W2070426078 @default.
• W2024480425 cites W2086431820 @default.
• W2024480425 cites W2096609449 @default.
• W2024480425 cites W2108038530 @default.
• W2024480425 cites W2119316269 @default.
• W2024480425 cites W2122573361 @default.
• W2024480425 cites W2132227734 @default.
• W2024480425 cites W2135801344 @default.
• W2024480425 cites W2140034535 @default.
• W2024480425 cites W2151665882 @default.
• W2024480425 cites W2165201727 @default.
• W2024480425 doi "https://doi.org/10.1371/journal.pone.0057732" @default.
• W2024480425 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3585800" @default.
• W2024480425 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23469224" @default.
• W2024480425 hasPublicationYear "2013" @default.
• W2024480425 type Work @default.
• W2024480425 sameAs 2024480425 @default.
• W2024480425 citedByCount "45" @default.
• W2024480425 countsByYear W20244804252013 @default.
• W2024480425 countsByYear W20244804252014 @default.
• W2024480425 countsByYear W20244804252015 @default.
• W2024480425 countsByYear W20244804252016 @default.
• W2024480425 countsByYear W20244804252017 @default.
• W2024480425 countsByYear W20244804252018 @default.
• W2024480425 countsByYear W20244804252019 @default.
• W2024480425 countsByYear W20244804252021 @default.
• W2024480425 countsByYear W20244804252022 @default.
• W2024480425 countsByYear W20244804252023 @default.
• W2024480425 crossrefType "journal-article" @default.
• W2024480425 hasAuthorship W2024480425A5015391354 @default.
• W2024480425 hasAuthorship W2024480425A5024792434 @default.
• W2024480425 hasAuthorship W2024480425A5029014004 @default.
• W2024480425 hasAuthorship W2024480425A5040189982 @default.
• W2024480425 hasAuthorship W2024480425A5046014971 @default.
• W2024480425 hasAuthorship W2024480425A5055129897 @default.
• W2024480425 hasAuthorship W2024480425A5055960115 @default.
• W2024480425 hasAuthorship W2024480425A5065047234 @default.
• W2024480425 hasAuthorship W2024480425A5076357748 @default.
• W2024480425 hasAuthorship W2024480425A5088519518 @default.
• W2024480425 hasBestOaLocation W20244804251 @default.
• W2024480425 hasConcept C123012128 @default.
• W2024480425 hasConcept C126322002 @default.
• W2024480425 hasConcept C16685009 @default.
• W2024480425 hasConcept C185592680 @default.
• W2024480425 hasConcept C196843134 @default.
• W2024480425 hasConcept C202751555 @default.
• W2024480425 hasConcept C2776151105 @default.
• W2024480425 hasConcept C2777043721 @default.
• W2024480425 hasConcept C2780394083 @default.
• W2024480425 hasConcept C2781321622 @default.
• W2024480425 hasConcept C31903555 @default.
• W2024480425 hasConcept C48349386 @default.
• W2024480425 hasConcept C55493867 @default.
• W2024480425 hasConcept C60781801 @default.
• W2024480425 hasConcept C71924100 @default.
• W2024480425 hasConcept C86803240 @default.
• W2024480425 hasConcept C87073359 @default.
• W2024480425 hasConcept C95444343 @default.
• W2024480425 hasConcept C97230052 @default.
• W2024480425 hasConceptScore W2024480425C123012128 @default.
• W2024480425 hasConceptScore W2024480425C126322002 @default.
• W2024480425 hasConceptScore W2024480425C16685009 @default.
• W2024480425 hasConceptScore W2024480425C185592680 @default.
• W2024480425 hasConceptScore W2024480425C196843134 @default.
• W2024480425 hasConceptScore W2024480425C202751555 @default.
• W2024480425 hasConceptScore W2024480425C2776151105 @default.
• W2024480425 hasConceptScore W2024480425C2777043721 @default.
• W2024480425 hasConceptScore W2024480425C2780394083 @default.
• W2024480425 hasConceptScore W2024480425C2781321622 @default.

• next