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- W2024481057 abstract "Dual antiplatelet therapy with aspirin (Asa) and clopidogrel (Clopi) is the cornerstone of treatment for patients (pts) after angioplasty (PCI). The state of dual antiplatelet responsiveness is not well known especially in elderly pts. The aim of this monocentric prospective observational study is to evaluate Asa and Clopi activity after PCI in elderly pts and to asses the evolution of this responsiveness at 5 weeks. We enrolled 81 elderly pts (≥75 years) from Jan to Dec 2008 on Asa (75 mg/day ≥ 7 days) and Clopi (after loading dose 300 mg before PCI and 150mg/day for 4 weeks fellowed by 75 mg/day for 1 year). We used the VerifyNow Asa assay and the VerifyNow Clopi P2Y12 assay (Accumetrics Inc, USA) to determinate respectively Asa and Clopi responsiveness in-hospital at 11.30 am (T1) and during a medical consultation at 5 weeks (T2). Asa non responders were noted in 10% and in 14% pts at respectively T1 and T2, Clopi non responders in 37% and in 70% pts at respectively T1 and T2. Significant changes were observed in Clopi response from responder to non responder (p < 0.001); similarly changes were noticed but in both ways for Asa response from T1 to T2 (p=0.005). Mutivariate analysis revelead plasma-HDL-cholesterol (OR [0.81]; 95% CI[0.67 to 0.98];p=0.031; for a raising of 0.1 mmol/L) and hematocrit level (OR [0.85]; 95% CI [0.75 to 0.96]; p=0.008 for an increasing of 1%) to be independent predictors of Clopi non responsiveness at T1; in the same way diabetes (OR [0.30]; 95% CI [0.10 to 0.95]; p=0.041; for non diabetes vs diabetes) and hematocrit level (OR [0.8]; 95% CI [0.77 to 1.00]; p=0.045 for an increasing of 1%) are independtly associated with Clopi non responsiveness at T2. In elderly, after PCI, there are changes in dual antiplatelet responsiveness between tests in-hospital and at 5 weeks marked for Clopi activity. Low hematocrit remains an independent predictor of Clopi non responsiveness." @default.
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- W2024481057 date "2010-01-01" @default.
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- W2024481057 title "044 Natural History Of Dual Anti-Platelet Responsiveness After Angioplasty In Elderly Patients" @default.
- W2024481057 doi "https://doi.org/10.1016/s1878-6480(10)70046-x" @default.
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