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• W2024481395 abstract "ObjectiveEstrogen is central to the initiation of human parturition, and placental aromatase controls estrogen biosynthesis in the fetoplacental unit. We sought to determine whether the known interplacental variability of microsomal aromatase activity is associated with maternal-fetal or gestational characteristics.Study DesignThree hundred human placentas were obtained immediately after delivery and villous tissue was randomly sampled. Homogenized tissue was processed to yield microsomal fractions; their protein concentration and aromatase activity was determined at 37oC. Medical records were reviewed, maternal-fetal and gestational characteristics recorded and appropriate statistical analyses performed (t-test, ANOVA, multiple regression analysis).ResultsWe confirmed the wide interplacental variance of microsomal aromatase activity: mean=272, standard deviation (SD)=95 pmolmin-1mg protein-1. Maternal race/ethnicity [Caucasian, African-American, Hispanic mean activity and SD: 271 and 91, 273 and 116, 272 and 89, respectively], fetal gender [male vs. female mean and SD: 263 and 90 vs. 278 and 92, respectively] and maternal smoking [smoking vs. non-smoking mean and SD: 259 and 80 vs. 270 and 86] had no significant effect on aromatase activity. Aromatase activity was statistically significantly lower in placentas from women delivering vaginally [vaginal vs. cesarean delivery mean and SD: 249 and 78 vs. 280 and 99, p<0.05 - did not persist on multiple regression analysis], in parturients [labor vs. no labor mean and SD: 259 and 87 vs. 290 and 101, p<0.05], and in preterm deliveries [preterm vs. term mean and SD: 251 and 87 vs. 283 and 98, p<0.01].ConclusionAromatase activity in human placental microsomes is not linked to the maternal-fetal characteristics studied, but is decreased after labor and preterm birth. The wide interplacental variability in aromatase activity appears to be an inherent property of the human trophoblast. ObjectiveEstrogen is central to the initiation of human parturition, and placental aromatase controls estrogen biosynthesis in the fetoplacental unit. We sought to determine whether the known interplacental variability of microsomal aromatase activity is associated with maternal-fetal or gestational characteristics. Estrogen is central to the initiation of human parturition, and placental aromatase controls estrogen biosynthesis in the fetoplacental unit. We sought to determine whether the known interplacental variability of microsomal aromatase activity is associated with maternal-fetal or gestational characteristics. Study DesignThree hundred human placentas were obtained immediately after delivery and villous tissue was randomly sampled. Homogenized tissue was processed to yield microsomal fractions; their protein concentration and aromatase activity was determined at 37oC. Medical records were reviewed, maternal-fetal and gestational characteristics recorded and appropriate statistical analyses performed (t-test, ANOVA, multiple regression analysis). Three hundred human placentas were obtained immediately after delivery and villous tissue was randomly sampled. Homogenized tissue was processed to yield microsomal fractions; their protein concentration and aromatase activity was determined at 37oC. Medical records were reviewed, maternal-fetal and gestational characteristics recorded and appropriate statistical analyses performed (t-test, ANOVA, multiple regression analysis). ResultsWe confirmed the wide interplacental variance of microsomal aromatase activity: mean=272, standard deviation (SD)=95 pmolmin-1mg protein-1. Maternal race/ethnicity [Caucasian, African-American, Hispanic mean activity and SD: 271 and 91, 273 and 116, 272 and 89, respectively], fetal gender [male vs. female mean and SD: 263 and 90 vs. 278 and 92, respectively] and maternal smoking [smoking vs. non-smoking mean and SD: 259 and 80 vs. 270 and 86] had no significant effect on aromatase activity. Aromatase activity was statistically significantly lower in placentas from women delivering vaginally [vaginal vs. cesarean delivery mean and SD: 249 and 78 vs. 280 and 99, p<0.05 - did not persist on multiple regression analysis], in parturients [labor vs. no labor mean and SD: 259 and 87 vs. 290 and 101, p<0.05], and in preterm deliveries [preterm vs. term mean and SD: 251 and 87 vs. 283 and 98, p<0.01]. We confirmed the wide interplacental variance of microsomal aromatase activity: mean=272, standard deviation (SD)=95 pmolmin-1mg protein-1. Maternal race/ethnicity [Caucasian, African-American, Hispanic mean activity and SD: 271 and 91, 273 and 116, 272 and 89, respectively], fetal gender [male vs. female mean and SD: 263 and 90 vs. 278 and 92, respectively] and maternal smoking [smoking vs. non-smoking mean and SD: 259 and 80 vs. 270 and 86] had no significant effect on aromatase activity. Aromatase activity was statistically significantly lower in placentas from women delivering vaginally [vaginal vs. cesarean delivery mean and SD: 249 and 78 vs. 280 and 99, p<0.05 - did not persist on multiple regression analysis], in parturients [labor vs. no labor mean and SD: 259 and 87 vs. 290 and 101, p<0.05], and in preterm deliveries [preterm vs. term mean and SD: 251 and 87 vs. 283 and 98, p<0.01]. ConclusionAromatase activity in human placental microsomes is not linked to the maternal-fetal characteristics studied, but is decreased after labor and preterm birth. The wide interplacental variability in aromatase activity appears to be an inherent property of the human trophoblast. Aromatase activity in human placental microsomes is not linked to the maternal-fetal characteristics studied, but is decreased after labor and preterm birth. The wide interplacental variability in aromatase activity appears to be an inherent property of the human trophoblast." @default.
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• W2024481395 title "219: Maternal-fetal gestational characteristics and microsomal aromatase activity in human placentas" @default.
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