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- W2024481540 abstract "Considering the significant role of plasma homocysteine in physiological processes, two ensembles (F465-Cu(2+) and F508-Cu(2+)) were constructed based on a BODIPY (4,4-difluoro-1,3,5,7-tetramethyl-4-bora-3a,4a-diaza-s-indacene) scaffold conjugated with an azamacrocyclic (1,4,7-triazacyclononane and 1,4,7,10-tetraazacyclododecane) Cu(2+) complex. The results of this effort demonstrated that the F465-Cu(2+) ensemble could be employed to detect homocysteine in the presence of other biologically relevant species, including cysteine and glutathione, under physiological conditions with high selectivity and sensitivity in the turn-on fluorescence mode, while the F508-Cu(2+) ensemble showed no fluorescence responses toward biothiols. A possible mechanism for this homocysteine-specific specificity involving the formation of a homocysteine-induced six-membered ring sandwich structure was proposed and confirmed for the first time by time-dependent fluorescence spectra, ESI-MS and EPR. The detection limit of homocysteine in deproteinized human serum was calculated to be 241.4 nM with a linear range of 0-90.0 μM and the detection limit of F465 for Cu(2+) is 74.7 nM with a linear range of 0-6.0 μM (F508, 80.2 nM, 0-7.0 μM). We have demonstrated the application of the F465-Cu(2+) ensemble for detecting homocysteine in human serum and monitoring the activity of cystathionine β-synthase in vitro." @default.
- W2024481540 created "2016-06-24" @default.
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- W2024481540 date "2015-10-01" @default.
- W2024481540 modified "2023-10-15" @default.
- W2024481540 title "BODIPY-based azamacrocyclic ensemble for selective fluorescence detection and quantification of homocysteine in biological applications" @default.
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- W2024481540 doi "https://doi.org/10.1016/j.bios.2015.04.085" @default.
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