Matches in SemOpenAlex for { <https://semopenalex.org/work/W2024483876> ?p ?o ?g. }
Showing items 1 to 70 of
70
with 100 items per page.
- W2024483876 endingPage "143" @default.
- W2024483876 startingPage "135" @default.
- W2024483876 abstract "The contribution of genetic background in susceptibility to hyperoxic lung injury is not clear. We utilized inbred mice to: 1) characterize inter-strain variation in hyperoxia-induced effects on lavageable indicators of airway epithelial injury; 2) test the hypothesis that hyperoxia-induced change in airway permeability is under Mendelian control. Male mice (5–7 wk, 20–25 g) from six inbred strains were exposed to 95–99% oxygen (O2) or room air for 0, 48, or 72 h. Hyperoxia-induced alteration in lung permeability was estimated by changes in lung wet weight: dry weight ratio and total bronchoalveolar lavage (BAL) protein concentration. The airway inflammatory response to O2 was assessed by changes in cellular profiles in BAL fluid. At least two distinct phenotypes were found among the strains exposed to O2 for 72 h. The susceptible phenotype (exemplified by C57BL/6J [B6] mice) was characterized by mean BAL protein concentration that was approximately 10 times greater than the resistant phenotype (e.g. C3H/HeJ [C3] mice). Hyperoxia caused LWW: LDW to double in susceptible B6 mice relative to controls, while no significant change was found in resistant C3 mice. Compared to air-exposed controls, hyperoxia also decreased the mean number of BAL alveolar macrophages and increased polymorphonuclear leukocytes in B6 mice, but the inflammatory cell profile of C3 mice was not affected after 72 h. The observed ratios of resistant to susceptible phenotypes of F1 F2, and back-cross progeny from B6 and C3 progenitors were not consistent with the hypothesis that susceptibility to hyperoxia is under Mendelian control. Inter-strain differences in hyperoxic lung injury suggest that genetic background contributes significantly to susceptibility, but the mode of inheritance is not clear. This model should prove useful for investigations of mechanisms and factors that may contribute to the variability in pulmonary responses to O2." @default.
- W2024483876 created "2016-06-24" @default.
- W2024483876 creator A5011001969 @default.
- W2024483876 creator A5017639654 @default.
- W2024483876 creator A5042008454 @default.
- W2024483876 date "1993-06-01" @default.
- W2024483876 modified "2023-10-15" @default.
- W2024483876 title "Inter-strain variation in susceptibility to hyperoxic injury of murine airways" @default.
- W2024483876 doi "https://doi.org/10.1097/00008571-199306000-00003" @default.
- W2024483876 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8334438" @default.
- W2024483876 hasPublicationYear "1993" @default.
- W2024483876 type Work @default.
- W2024483876 sameAs 2024483876 @default.
- W2024483876 citedByCount "68" @default.
- W2024483876 countsByYear W20244838762012 @default.
- W2024483876 countsByYear W20244838762013 @default.
- W2024483876 countsByYear W20244838762014 @default.
- W2024483876 countsByYear W20244838762015 @default.
- W2024483876 countsByYear W20244838762016 @default.
- W2024483876 countsByYear W20244838762019 @default.
- W2024483876 crossrefType "journal-article" @default.
- W2024483876 hasAuthorship W2024483876A5011001969 @default.
- W2024483876 hasAuthorship W2024483876A5017639654 @default.
- W2024483876 hasAuthorship W2024483876A5042008454 @default.
- W2024483876 hasConcept C104317684 @default.
- W2024483876 hasConcept C126322002 @default.
- W2024483876 hasConcept C127716648 @default.
- W2024483876 hasConcept C16685009 @default.
- W2024483876 hasConcept C203014093 @default.
- W2024483876 hasConcept C2777714996 @default.
- W2024483876 hasConcept C2777961210 @default.
- W2024483876 hasConcept C2780672939 @default.
- W2024483876 hasConcept C54355233 @default.
- W2024483876 hasConcept C71924100 @default.
- W2024483876 hasConcept C76725341 @default.
- W2024483876 hasConcept C86803240 @default.
- W2024483876 hasConceptScore W2024483876C104317684 @default.
- W2024483876 hasConceptScore W2024483876C126322002 @default.
- W2024483876 hasConceptScore W2024483876C127716648 @default.
- W2024483876 hasConceptScore W2024483876C16685009 @default.
- W2024483876 hasConceptScore W2024483876C203014093 @default.
- W2024483876 hasConceptScore W2024483876C2777714996 @default.
- W2024483876 hasConceptScore W2024483876C2777961210 @default.
- W2024483876 hasConceptScore W2024483876C2780672939 @default.
- W2024483876 hasConceptScore W2024483876C54355233 @default.
- W2024483876 hasConceptScore W2024483876C71924100 @default.
- W2024483876 hasConceptScore W2024483876C76725341 @default.
- W2024483876 hasConceptScore W2024483876C86803240 @default.
- W2024483876 hasIssue "3" @default.
- W2024483876 hasLocation W20244838761 @default.
- W2024483876 hasLocation W20244838762 @default.
- W2024483876 hasOpenAccess W2024483876 @default.
- W2024483876 hasPrimaryLocation W20244838761 @default.
- W2024483876 hasRelatedWork W1487713416 @default.
- W2024483876 hasRelatedWork W1820752468 @default.
- W2024483876 hasRelatedWork W1990419880 @default.
- W2024483876 hasRelatedWork W2008590349 @default.
- W2024483876 hasRelatedWork W2370428237 @default.
- W2024483876 hasRelatedWork W2373328535 @default.
- W2024483876 hasRelatedWork W2375669759 @default.
- W2024483876 hasRelatedWork W2387973921 @default.
- W2024483876 hasRelatedWork W2931640887 @default.
- W2024483876 hasRelatedWork W3048766942 @default.
- W2024483876 hasVolume "3" @default.
- W2024483876 isParatext "false" @default.
- W2024483876 isRetracted "false" @default.
- W2024483876 magId "2024483876" @default.
- W2024483876 workType "article" @default.