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• W2024484119 abstract "In many rural communities of Africa, indigenous health-care practitioners locally known as ‘traditional healers’, are the only ‘medical’ practitioners available for the peoples’ health-care needs. These traditional healers usually employ an array of medicinal plants to treat or manage a plethora of human ailments, including essential hypertension (EH). Previous scientific studies have shown that extractives from certain African medicinal plants are useful remedies for the control and/or management of high blood pressure (BP). Leonotis leonurus (Linn.) R. Br. [Lamiaceae] is one of the several African medicinal plants commonly used by some South African traditional healers to manage or control essential hypertension. However, there is no data available in the medical literature to substantiate the therapeutic application of Leonotis leonurus in hypertension. The cardiovascular effects of an aqueous leaf extract of Leonotis leonurus were, therefore, investigated on the arterial blood pressures and heart rates of normal and spontaneously hypertensive rats, using invasive and non-invasive techniques. The aqueous leaf extract of L. leonurus (LL, 25 – 800 mg/kg i. v.) produced dose-related, significant decreases (P < 0.05 – 0.001) in the arterial blood pressures and heart rates of anaesthetized, normal and spontaneously hypertensive rats. The hypotensive effect of the leaf extract was more pronounced in the hypertensive rats than in the normal ones. The aqueous leaf extract of the plant (LL, 25 – 800 mg/kg i. p.) also decreased, in a dose-dependent fashion, the arterial blood pressures and heart rates of conscious, normal and spontaneously hypertensive rats. The depressor effects of the plant extract were not modified by pre-treatment of the animals with atropine (20 mg/kg i.p.) or mepyramine (20 mg/kg i. p.). Furthermore, the plant extract (LL, 25 – 800 μg/ml) relaxed, in a non-specific manner, bath-applied noradrenaline (NA, 0.1–10 μM)-, potassium (K+, 5/40 mM)- and other vascular smooth muscle agonist- induced contractions of the rat isolated descending aortic strips and portal veins suspended in normal Krebs-Henseleit solution under physiological conditions. The experimental evidence obtained in this laboratory animal study suggests that Leonotis leonurus aqueous leaf extract possesses hypotensive activity, and thus lends credence to the folkloric use of this perennial shrub as a natural, herbal remedy for the control and/or management of hypertension in certain communities of South Africa." @default.
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• W2024484119 date "2003-05-01" @default.
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• W2024484119 title "Hypotensive effect of Leonotis leonurus aqueous leaf extract in rats" @default.
• W2024484119 doi "https://doi.org/10.1016/s0895-7061(03)00168-7" @default.
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