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• W2024484232 abstract "In Brief BACKGROUND: Acute renal failure is a frequent complication of sepsis. Hydroxyethyl starch (HES) is widely used in the treatment of such patients. However, the effect of HES on renal function during sepsis remains controversial. We established an in vitro model of tumor necrosis factor-α (TNF-α)-stimulated human proximal tubular epithelial (HK-2) cells to assess the possible effects of HES 130/0.42 and HES 200/0.5 on these activated cells. METHODS: HK-2 cells were stimulated with TNF-α in the presence or absence of HES 130/0.42 or 200/0.5. After 4, 10, and 18 h of incubation, monocyte chemoattractant protein-1 (MCP-1), a key chemoattractant for neutrophils and macrophages, was measured. In addition, viability and cytotoxicity assays were performed. RESULTS: MCP-1 expression was doubled upon TNF-α exposure. In the presence of 2% and 4% HES 200/0.5 in 98% (96%) medium over a stimulation time period of 10 h and 18 h, the MCP-1 concentration was decreased between 26% and 56% (P < 0.05). TNF-α stimulation resulted in a significant decrease of viability by 53%–63%, whereas viability decreased by only 32%–40% in coincubation with HES 130/0.42 (P < 0.005) and remained even less affected by TNF-α in the presence of HES 200/0.5 (P < 0.001). The TNF-α–induced cell death rate was attenuated in the presence of HES 200/0.5 (P < 0.05). CONCLUSIONS: This in vitro study shows that both HES products modulate cell injury upon inflammatory stimulation. The effect was more pronounced in the HES 200/0.5 group than for HES 130/0.42, suggesting a possible biological difference between the HES types. Published ahead of print November 12, 2009" @default.
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• W2024484232 date "2010-02-01" @default.
• W2024484232 modified "2023-10-13" @default.
• W2024484232 title "The Effect of Hydroxyethyl Starches (HES 130/0.42 and HES 200/0.5) on Activated Renal Tubular Epithelial Cells" @default.
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• W2024484232 doi "https://doi.org/10.1213/ane.0b013e3181c03c97" @default.
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