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- W2024485794 abstract "CTRC-AACR San Antonio Breast Cancer Symposium: 2008 AbstractsAbstract #3014 Introduction: Ductal carcinoma in situ (DCIS) of the breast is defined as a proliferation of malignant epithelial cells within breast ducts without evidence of invasion through the basement membrane. Core needle biopsy (CNB) is used to sample both symptomatic and screen detected breast lesions preoperatively. However in a proportion of patients invasive disease is identified following surgical excision and as a result an upstaged patient may need to undergo additional surgery for axillary nodal evaluation such as sentinel lymph node biopsy (SLNB). Our aim was to evaluate predictive factors for invasive disease in this group. Method: Data from all patients with preoperative diagnosis of DCIS on core biopsy between February 2006 and December 2007 were analysed. Demographic data, screening /symptomatic presentation, palpability, size and histological features of DCIS on core biopsy including presence/absence of comedo necrosis, size of post operative invasion when present and result of axillary staging in this group was recorded. All patients with invasive disease had axillary staging. Results: A total of 75 patients were identified (all female), median age 63 (range 38-77). 72% (54/75) were screen detected. All palpable lesions were in the symptomatic group (13/19). Invasive disease was identified in 18 (24%) on post operative histology (2 micro-invasions). Only one patient with invasive disease had axillary involvement. ![][1] Invasive disease was significantly higher in symptomatic and palpable lesions (P=0.04). Size of the lesion was significantly larger in the invasive group (P=0.04). High grade histology or presence of comedo necrosis was not a predictor of invasive disease in our series. Conclusion: A quarter of patients were upstaged and required axillary staging. 50% of symptomatic, palpable lesions larger than 20mm were found to be invasive on final histology, this group accounted for the only positive axilla. Symptomatic patients presenting with large, palpable areas of DCIS should be considered for axillary ultrasound scan and/or SLNB.Citation Information: Cancer Res 2009;69(2 Suppl):Abstract nr 3014. [1]: /embed/graphic-1.gif" @default.
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- W2024485794 date "2009-01-15" @default.
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- W2024485794 title "Are there preoperative predictors for invasive disease in DCIS?." @default.
- W2024485794 doi "https://doi.org/10.1158/0008-5472.sabcs-3014" @default.
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!["CTRC-AACR San Antonio Breast Cancer Symposium: 2008 AbstractsAbstract #3014 Introduction: Ductal carcinoma in situ (DCIS) of the breast is defined as a proliferation of malignant epithelial cells within breast ducts without evidence of invasion through the basement membrane. Core needle biopsy (CNB) is used to sample both symptomatic and screen detected breast lesions preoperatively. However in a proportion of patients invasive disease is identified following surgical excision and as a result an upstaged patient may need to undergo additional surgery for axillary nodal evaluation such as sentinel lymph node biopsy (SLNB). Our aim was to evaluate predictive factors for invasive disease in this group. Method: Data from all patients with preoperative diagnosis of DCIS on core biopsy between February 2006 and December 2007 were analysed. Demographic data, screening /symptomatic presentation, palpability, size and histological features of DCIS on core biopsy including presence/absence of comedo necrosis, size of post operative invasion when present and result of axillary staging in this group was recorded. All patients with invasive disease had axillary staging. Results: A total of 75 patients were identified (all female), median age 63 (range 38-77). 72% (54/75) were screen detected. All palpable lesions were in the symptomatic group (13/19). Invasive disease was identified in 18 (24%) on post operative histology (2 micro-invasions). Only one patient with invasive disease had axillary involvement. ![][1] Invasive disease was significantly higher in symptomatic and palpable lesions (P=0.04). Size of the lesion was significantly larger in the invasive group (P=0.04). High grade histology or presence of comedo necrosis was not a predictor of invasive disease in our series. Conclusion: A quarter of patients were upstaged and required axillary staging. 50% of symptomatic, palpable lesions larger than 20mm were found to be invasive on final histology, this group accounted for the only positive axilla. Symptomatic patients presenting with large, palpable areas of DCIS should be considered for axillary ultrasound scan and/or SLNB.Citation Information: Cancer Res 2009;69(2 Suppl):Abstract nr 3014. [1]: /embed/graphic-1.gif"](?object=%22CTRC-AACR%20San%20Antonio%20Breast%20Cancer%20Symposium%3A%202008%20AbstractsAbstract%20%233014%20Introduction%3A%20Ductal%20carcinoma%20in%20situ%20(DCIS)%20of%20the%20breast%20is%20defined%20as%20a%20proliferation%20of%20malignant%20epithelial%20cells%20within%20breast%20ducts%20without%20evidence%20of%20invasion%20through%20the%20basement%20membrane.%20Core%20needle%20biopsy%20(CNB)%20is%20used%20to%20sample%20both%20symptomatic%20and%20screen%20detected%20breast%20lesions%20preoperatively.%20However%20in%20a%20proportion%20of%20patients%20invasive%20disease%20is%20identified%20following%20surgical%20excision%20and%20as%20a%20result%20an%20upstaged%20patient%20may%20need%20to%20undergo%20additional%20surgery%20for%20axillary%20nodal%20evaluation%20such%20as%20sentinel%20lymph%20node%20biopsy%20(SLNB).%20Our%20aim%20was%20to%20evaluate%20predictive%20factors%20for%20invasive%20disease%20in%20this%20group.%20Method%3A%20Data%20from%20all%20patients%20with%20preoperative%20diagnosis%20of%20DCIS%20on%20core%20biopsy%20between%20February%202006%20and%20December%202007%20were%20analysed.%20Demographic%20data%2C%20screening%20%2Fsymptomatic%20presentation%2C%20palpability%2C%20size%20and%20histological%20features%20of%20DCIS%20on%20core%20biopsy%20including%20presence%2Fabsence%20of%20comedo%20necrosis%2C%20size%20of%20post%20operative%20invasion%20when%20present%20and%20result%20of%20axillary%20staging%20in%20this%20group%20was%20recorded.%20All%20patients%20with%20invasive%20disease%20had%20axillary%20staging.%20Results%3A%20A%20total%20of%2075%20patients%20were%20identified%20(all%20female)%2C%20median%20age%2063%20(range%2038-77).%2072%25%20(54%2F75)%20were%20screen%20detected.%20All%20palpable%20lesions%20were%20in%20the%20symptomatic%20group%20(13%2F19).%20Invasive%20disease%20was%20identified%20in%2018%20(24%25)%20on%20post%20operative%20histology%20(2%20micro-invasions).%20Only%20one%20patient%20with%20invasive%20disease%20had%20axillary%20involvement.%20!%5B%5D%5B1%5D%20Invasive%20disease%20was%20significantly%20higher%20in%20symptomatic%20and%20palpable%20lesions%20(P%3D0.04).%20Size%20of%20the%20lesion%20was%20significantly%20larger%20in%20the%20invasive%20group%20(P%3D0.04).%20High%20grade%20histology%20or%20presence%20of%20comedo%20necrosis%20was%20not%20a%20predictor%20of%20invasive%20disease%20in%20our%20series.%20Conclusion%3A%20A%20quarter%20of%20patients%20were%20upstaged%20and%20required%20axillary%20staging.%2050%25%20of%20symptomatic%2C%20palpable%20lesions%20larger%20than%2020mm%20were%20found%20to%20be%20invasive%20on%20final%20histology%2C%20this%20group%20accounted%20for%20the%20only%20positive%20axilla.%20Symptomatic%20patients%20presenting%20with%20large%2C%20palpable%20areas%20of%20DCIS%20should%20be%20considered%20for%20axillary%20ultrasound%20scan%20and%2For%20SLNB.Citation%20Information%3A%20Cancer%20Res%202009%3B69(2%20Suppl)%3AAbstract%20nr%203014.%20%5B1%5D%3A%20%2Fembed%2Fgraphic-1.gif%22){kind=link}