FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2024485909> ?p ?o ?g. }

• W2024485909 endingPage "e70502" @default.
• W2024485909 startingPage "e70502" @default.
• W2024485909 abstract "Germline cyst formation is essential for the propagation of many organisms including humans and flies. The cytoplasm of germline cyst cells communicate with each other directly via large intercellular bridges called ring canals. Ring canals are often derived from arrested contractile rings during incomplete cytokinesis. However how ring canal formation, maintenance and growth are regulated remains unclear. To better understand this process, we carried out an unbiased genetic screen in Drosophila melanogaster germ cells and identified multiple alleles of flapwing (flw), a conserved serine/threonine-specific protein phosphatase. Flw had previously been reported to be unnecessary for early D. melanogaster oogenesis using a hypomorphic allele. We found that loss of Flw leads to over-constricted nascent ring canals and subsequently tiny mature ring canals, through which cytoplasmic transfer from nurse cells to the oocyte is impaired, resulting in small, non-functional eggs. Flw is expressed in germ cells undergoing incomplete cytokinesis, completely colocalized with the Drosophila myosin binding subunit of myosin phosphatase (DMYPT). This colocalization, together with genetic interaction studies, suggests that Flw functions together with DMYPT to negatively regulate myosin activity during ring canal formation. The identification of two subunits of the tripartite myosin phosphatase as the first two main players required for ring canal constriction indicates that tight regulation of myosin activity is essential for germline cyst formation and reproduction in D. melanogaster and probably other species as well." @default.
• W2024485909 created "2016-06-24" @default.
• W2024485909 creator A5011473722 @default.
• W2024485909 creator A5026995692 @default.
• W2024485909 creator A5057005768 @default.
• W2024485909 creator A5057632716 @default.
• W2024485909 date "2013-07-25" @default.
• W2024485909 modified "2023-10-14" @default.
• W2024485909 title "Protein Phosphatase 1ß Limits Ring Canal Constriction during Drosophila Germline Cyst Formation" @default.
• W2024485909 cites W1850025117 @default.
• W2024485909 cites W1938204331 @default.
• W2024485909 cites W1968050693 @default.
• W2024485909 cites W1984994493 @default.
• W2024485909 cites W1987966101 @default.
• W2024485909 cites W1990123974 @default.
• W2024485909 cites W2006681960 @default.
• W2024485909 cites W2014718329 @default.
• W2024485909 cites W2019561456 @default.
• W2024485909 cites W2019808498 @default.
• W2024485909 cites W2021541131 @default.
• W2024485909 cites W2022127993 @default.
• W2024485909 cites W2023446937 @default.
• W2024485909 cites W2024829097 @default.
• W2024485909 cites W2028638994 @default.
• W2024485909 cites W2035313584 @default.
• W2024485909 cites W2036338354 @default.
• W2024485909 cites W2036412640 @default.
• W2024485909 cites W2037386843 @default.
• W2024485909 cites W2038262197 @default.
• W2024485909 cites W2042971581 @default.
• W2024485909 cites W2049863303 @default.
• W2024485909 cites W2051830662 @default.
• W2024485909 cites W2052190647 @default.
• W2024485909 cites W2055028307 @default.
• W2024485909 cites W2066526426 @default.
• W2024485909 cites W2073761355 @default.
• W2024485909 cites W2101027598 @default.
• W2024485909 cites W2101151408 @default.
• W2024485909 cites W2110117704 @default.
• W2024485909 cites W2110643873 @default.
• W2024485909 cites W2111196974 @default.
• W2024485909 cites W2112494447 @default.
• W2024485909 cites W2114836858 @default.
• W2024485909 cites W2118806304 @default.
• W2024485909 cites W2125545718 @default.
• W2024485909 cites W2126391346 @default.
• W2024485909 cites W2127504108 @default.
• W2024485909 cites W2132749205 @default.
• W2024485909 cites W2133960469 @default.
• W2024485909 cites W2152018084 @default.
• W2024485909 cites W2153863158 @default.
• W2024485909 cites W2157257075 @default.
• W2024485909 cites W2157818884 @default.
• W2024485909 cites W2157934217 @default.
• W2024485909 cites W2159207718 @default.
• W2024485909 cites W2166519728 @default.
• W2024485909 cites W2410651335 @default.
• W2024485909 cites W4247515832 @default.
• W2024485909 doi "https://doi.org/10.1371/journal.pone.0070502" @default.
• W2024485909 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3723691" @default.
• W2024485909 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23936219" @default.
• W2024485909 hasPublicationYear "2013" @default.
• W2024485909 type Work @default.
• W2024485909 sameAs 2024485909 @default.
• W2024485909 citedByCount "27" @default.
• W2024485909 countsByYear W20244859092014 @default.
• W2024485909 countsByYear W20244859092015 @default.
• W2024485909 countsByYear W20244859092016 @default.
• W2024485909 countsByYear W20244859092017 @default.
• W2024485909 countsByYear W20244859092018 @default.
• W2024485909 countsByYear W20244859092019 @default.
• W2024485909 countsByYear W20244859092020 @default.
• W2024485909 countsByYear W20244859092022 @default.
• W2024485909 countsByYear W20244859092023 @default.
• W2024485909 crossrefType "journal-article" @default.
• W2024485909 hasAuthorship W2024485909A5011473722 @default.
• W2024485909 hasAuthorship W2024485909A5026995692 @default.
• W2024485909 hasAuthorship W2024485909A5057005768 @default.
• W2024485909 hasAuthorship W2024485909A5057632716 @default.
• W2024485909 hasBestOaLocation W20244859091 @default.
• W2024485909 hasConcept C104317684 @default.
• W2024485909 hasConcept C105702510 @default.
• W2024485909 hasConcept C109825262 @default.
• W2024485909 hasConcept C134305767 @default.
• W2024485909 hasConcept C1491633281 @default.
• W2024485909 hasConcept C2780104201 @default.
• W2024485909 hasConcept C45472230 @default.
• W2024485909 hasConcept C54355233 @default.
• W2024485909 hasConcept C6997183 @default.
• W2024485909 hasConcept C85813293 @default.
• W2024485909 hasConcept C86803240 @default.
• W2024485909 hasConcept C95444343 @default.
• W2024485909 hasConceptScore W2024485909C104317684 @default.
• W2024485909 hasConceptScore W2024485909C105702510 @default.
• W2024485909 hasConceptScore W2024485909C109825262 @default.
• W2024485909 hasConceptScore W2024485909C134305767 @default.
• W2024485909 hasConceptScore W2024485909C1491633281 @default.
• W2024485909 hasConceptScore W2024485909C2780104201 @default.

• next