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- W2024486718 abstract "To the Editor.— The recent report by Schwartz1describing the use of halothane to treat status asthmaticus unresponsive to other therapy serves as a useful reminder to the medical community. However, several important clarifications should be made. First, the initial treatment in case 2 was suboptimal. Clearly, arterial hypoxemia (Pao2, 61 mm Hg) and hypercarbia (Pco2, 123 mm Hg) of this magnitude, along with patient lethargy, mandate immediate mechanical ventilation. Furthermore, administration of sodium bicarbonate for the treatment of respiratory acidosis without mechanical ventilation will only produce greater hypercarbia. Although Schwartz suggests that the use of succinylcholine is contraindicated in status asthmaticus because of histamine release, this is actually not a significant problem. Succinylcholine releases minimal amounts of histamine2; it is almost never a problem in clinical practice. A theoretical concern is its effect of activating all cholinergic autonomic receptors, thus increasing bronchospasm. A more practical" @default.
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- W2024486718 date "1985-01-18" @default.
- W2024486718 modified "2023-09-27" @default.
- W2024486718 title "Treatment of Status Asthmaticus" @default.
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- W2024486718 doi "https://doi.org/10.1001/jama.1985.03350270037009" @default.
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