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- W2024489323 abstract "Toll-like receptor (TLR) family members recognize specific molecular patterns within pathogens. Signaling through TLRs results in a proximal event that involves direct binding of adaptor proteins to the receptors. We observed that TIRAP/Mal, an adaptor protein for TLR2 and TLR4, binds protein kinase Cdelta (PKCdelta). TIRAP/Mal GST-fusion protein and a TIRAP/Mal antibody were able to precipitate PKCdelta from rat peritoneal macrophage and THP1 cell lysates. Truncation mutants of TIRAP/Mal showed that the TIR domain of TIRAP/Mal is responsible for binding. TLR2- and TLR4-mediated phosphorylation of p38 MAPK, IKK, and IkappaB in RAW264.7 cells were abolished by depletion of PKCdelta. These results suggest that PKCdelta binding to TIRAP/Mal promotes TLR signaling events." @default.
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- W2024489323 date "2007-03-01" @default.
- W2024489323 modified "2023-09-26" @default.
- W2024489323 title "Protein kinase Cδ binds TIRAP/Mal to participate in TLR signaling" @default.
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- W2024489323 doi "https://doi.org/10.1016/j.molimm.2006.11.005" @default.
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