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- W2024491237 abstract "A 65-year-old man was admitted to another hospital with a life-threatening brain haemorrhage, and laboratory examinations on admission revealed prolonged prothrombin time with normal activated partial thromboplastin time. To establish the cause of his abnormal coagulation, he was referred to our clinic. Neither the patient nor his family had any previous history of bleeding symptoms. His liver function was within normal limits but coagulation tests showed increased plasma activities of factors II, VIII, IX, X, with reduced activities of factors V and VII. The activity of factor VII was less than 2% but no inhibitor of factor VII was detected in the plasma. We concluded that the patient had a rare congenital isolated factor VII deficiency although he had not shown earlier bleeding problems, presumably because of compensation for the factor VII deficiency by enhanced activities of components of the extrinsic coagulation pathway, factors II, VIII, IX and X." @default.
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- W2024491237 date "2000-12-01" @default.
- W2024491237 modified "2023-10-15" @default.
- W2024491237 title "Isolated Factor VII Deficiency Diagnosed after a Life-Threatening Brain Haemorrhage" @default.
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- W2024491237 doi "https://doi.org/10.1177/147323000002800609" @default.
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