FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2024491277> ?p ?o ?g. }

• W2024491277 endingPage "36" @default.
• W2024491277 startingPage "22" @default.
• W2024491277 abstract "A photoreactivable variant (strainHr30-R), obtained from a radiation-resistant, argenine-requiring derivative (strainHr30) of Harm's non-photoreactivable (phr−) mutants of Escherichia coli B, is compared with its parent strain. The photoreversibility of UV-induced mutations to prototrophy is found to be about the same in the two strains. Since the phr− strain lacks the ability to split thymine dimers produced by UV in its DNA, but photreverses these mutations to the same extent as does the phr+ strain, it is concluded that the UV lesions leading to prototrophy are not thymine dimers. In experiments varying the time of exposure to photoreversing light, it is found that the efficiency of photoreversal of UV-induced prototrophy is considerably greater in the phr+ strain than in the phr− strain. This is interpreted as evidence that the photoreversal of preprototrophic damage is hindered by the presence of thymine dimers in the DNA. The efficiency of photoreversal of these mutations is also found to decrease with increasing UV dose in the phr− strain, lending further support to the conclusion that photoreversal of UV-induced prototrophy becomes less efficient as the number of thymine dimers in the DNA increases. In an experiment involving three successive exposures to UV, each followed by an incubation to allow “dark repair” of prototrophy induced by the preceding dose installment, the rate of “dark repair” is also found to decrease as thymine dimers accumulate in the DNA. These findings are interpreted as evidence that the UV damage leading to prototrophy is produced directly in DNA, and not in low-molecular-weight precursors of nucleic acid synthesis. Several mechanisms whereby thymine dimers might affect the efficiency of repair of the other UV lesions in the DNA are proposed. The possibility is discussed that photoreversal, photoprotection and “dark repair” may all be the same mechanism, insofar as UV-induced prototrophy is concerned, with the photoreversing or photoprotecting light acting indirectly, through the production of a delay in protein synthesis, thereby creating the conditions necessary for “dark repair”. It is further proposed that three classes of UV effects (UV killing in E. coli B, UV-induced prototrophy and UV induction of prophage), which share many pre- and post-irradiation responses, may all originate through the same kind of UV lesion, not the thymine dimer, associated with the detachment of integrated episomes." @default.
• W2024491277 created "2016-06-24" @default.
• W2024491277 creator A5039213904 @default.
• W2024491277 date "1964-05-01" @default.
• W2024491277 modified "2023-09-28" @default.
• W2024491277 title "Photoreversal and “dark repair” of mutations to prototrophy induced by ultraviolet light in photoreactivable and non-photoreactivable strains of Escherichia coli" @default.
• W2024491277 cites W1581851962 @default.
• W2024491277 cites W1898552622 @default.
• W2024491277 cites W1940758406 @default.
• W2024491277 cites W1966007698 @default.
• W2024491277 cites W1983791808 @default.
• W2024491277 cites W2033939606 @default.
• W2024491277 cites W2035292414 @default.
• W2024491277 cites W2038531066 @default.
• W2024491277 cites W2039369940 @default.
• W2024491277 cites W2043939065 @default.
• W2024491277 cites W2045360234 @default.
• W2024491277 cites W2049636481 @default.
• W2024491277 cites W2055602480 @default.
• W2024491277 cites W2073200951 @default.
• W2024491277 cites W2103728281 @default.
• W2024491277 cites W2113391614 @default.
• W2024491277 cites W2138190884 @default.
• W2024491277 cites W2143149259 @default.
• W2024491277 cites W2333675015 @default.
• W2024491277 cites W4211045924 @default.
• W2024491277 doi "https://doi.org/10.1016/0027-5107(64)90049-1" @default.
• W2024491277 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/14195747" @default.
• W2024491277 hasPublicationYear "1964" @default.
• W2024491277 type Work @default.
• W2024491277 sameAs 2024491277 @default.
• W2024491277 citedByCount "69" @default.
• W2024491277 countsByYear W20244912772015 @default.
• W2024491277 crossrefType "journal-article" @default.
• W2024491277 hasAuthorship W2024491277A5039213904 @default.
• W2024491277 hasConcept C104317684 @default.
• W2024491277 hasConcept C105702510 @default.
• W2024491277 hasConcept C143065580 @default.
• W2024491277 hasConcept C143425029 @default.
• W2024491277 hasConcept C153911025 @default.
• W2024491277 hasConcept C167975912 @default.
• W2024491277 hasConcept C185592680 @default.
• W2024491277 hasConcept C20950039 @default.
• W2024491277 hasConcept C2776858809 @default.
• W2024491277 hasConcept C2778022156 @default.
• W2024491277 hasConcept C54355233 @default.
• W2024491277 hasConcept C547475151 @default.
• W2024491277 hasConcept C552990157 @default.
• W2024491277 hasConcept C86803240 @default.
• W2024491277 hasConceptScore W2024491277C104317684 @default.
• W2024491277 hasConceptScore W2024491277C105702510 @default.
• W2024491277 hasConceptScore W2024491277C143065580 @default.
• W2024491277 hasConceptScore W2024491277C143425029 @default.
• W2024491277 hasConceptScore W2024491277C153911025 @default.
• W2024491277 hasConceptScore W2024491277C167975912 @default.
• W2024491277 hasConceptScore W2024491277C185592680 @default.
• W2024491277 hasConceptScore W2024491277C20950039 @default.
• W2024491277 hasConceptScore W2024491277C2776858809 @default.
• W2024491277 hasConceptScore W2024491277C2778022156 @default.
• W2024491277 hasConceptScore W2024491277C54355233 @default.
• W2024491277 hasConceptScore W2024491277C547475151 @default.
• W2024491277 hasConceptScore W2024491277C552990157 @default.
• W2024491277 hasConceptScore W2024491277C86803240 @default.
• W2024491277 hasIssue "1" @default.
• W2024491277 hasLocation W20244912771 @default.
• W2024491277 hasLocation W20244912772 @default.
• W2024491277 hasOpenAccess W2024491277 @default.
• W2024491277 hasPrimaryLocation W20244912771 @default.
• W2024491277 hasRelatedWork W2008980772 @default.
• W2024491277 hasRelatedWork W2024491277 @default.
• W2024491277 hasRelatedWork W2040785512 @default.
• W2024491277 hasRelatedWork W2056826119 @default.
• W2024491277 hasRelatedWork W2057829676 @default.
• W2024491277 hasRelatedWork W2096157677 @default.
• W2024491277 hasRelatedWork W2099138759 @default.
• W2024491277 hasRelatedWork W2135305503 @default.
• W2024491277 hasRelatedWork W3027204986 @default.
• W2024491277 hasRelatedWork W79776920 @default.
• W2024491277 hasVolume "1" @default.
• W2024491277 isParatext "false" @default.
• W2024491277 isRetracted "false" @default.
• W2024491277 magId "2024491277" @default.
• W2024491277 workType "article" @default.