FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2024491864> ?p ?o ?g. }

• W2024491864 endingPage "124" @default.
• W2024491864 startingPage "117" @default.
• W2024491864 abstract "Abstract The neuroprotective activity of a novel N ‐acylprolyl‐containing dipeptide analog of the nootropic 2‐oxo‐1‐pyrrolidine acetamide (Piracetam) designated as GVS‐111 (DVD‐111/Noopept) was tested in two in vitro models of neuronal degeneration mediated by oxidative stress: normal human cortical neurons treated with H 2 O 2 , and Down's syndrome (DS) cortical neurons. Incubation of normal cortical neurons with 50 μM H 2 O 2 for 1 h resulted in morphological and structural changes consistent with neuronal apoptosis and in the degeneration of more than 60% of the neurons present in the culture. GVS‐111 significantly increased neuronal survival after H 2 O 2 ‐treatment displaying a dose‐dependent neuroprotective activity from 10 nM to 100 μM, and an IC 50 value of 1.21±0.07 μM. GVS‐111 inhibited the accumulation of intracellular free radicals and lipid peroxidation damage in neurons treated with H 2 O 2 or FeSO 4 , suggesting an antioxidant mechanism of action. GVS‐111 exhibited significantly higher neuroprotection compared to the standard cognition enhancer Piracetam, or to the antioxidants Vitamin E, propyl gallate and N ‐ tert ‐butyl‐2‐sulpho‐phenylnitrone (s‐PBN). In DS cortical cultures, chronic treatment with GVS‐111 significantly reduced the appearance of degenerative changes and enhanced neuronal survival. The results suggest that the neuroprotective effect of GVS‐111 against oxidative damage and its potential nootropic activity may present a valuable therapeutic combination for the treatment of mental retardation and chronic neurodegenerative disorders." @default.
• W2024491864 created "2016-06-24" @default.
• W2024491864 creator A5014617287 @default.
• W2024491864 creator A5037422954 @default.
• W2024491864 creator A5045330820 @default.
• W2024491864 creator A5054045083 @default.
• W2024491864 creator A5067600290 @default.
• W2024491864 creator A5080614846 @default.
• W2024491864 date "2003-04-11" @default.
• W2024491864 modified "2023-09-27" @default.
• W2024491864 title "GVS‐111 prevents oxidative damage and apoptosis in normal and Down's syndrome human cortical neurons" @default.
• W2024491864 cites W1524335392 @default.
• W2024491864 cites W1545355559 @default.
• W2024491864 cites W1562586507 @default.
• W2024491864 cites W1940692702 @default.
• W2024491864 cites W1964247625 @default.
• W2024491864 cites W1968537977 @default.
• W2024491864 cites W1968687751 @default.
• W2024491864 cites W1976349180 @default.
• W2024491864 cites W1985542391 @default.
• W2024491864 cites W1992689843 @default.
• W2024491864 cites W1993772503 @default.
• W2024491864 cites W2010716981 @default.
• W2024491864 cites W2016882884 @default.
• W2024491864 cites W2018122947 @default.
• W2024491864 cites W2028104287 @default.
• W2024491864 cites W2034361661 @default.
• W2024491864 cites W2040118792 @default.
• W2024491864 cites W2046382181 @default.
• W2024491864 cites W2050012254 @default.
• W2024491864 cites W2051314670 @default.
• W2024491864 cites W2054562862 @default.
• W2024491864 cites W2062199825 @default.
• W2024491864 cites W2089316648 @default.
• W2024491864 cites W2096550955 @default.
• W2024491864 cites W2121042833 @default.
• W2024491864 cites W2136742966 @default.
• W2024491864 cites W2140075873 @default.
• W2024491864 cites W2158748165 @default.
• W2024491864 cites W2166291746 @default.
• W2024491864 doi "https://doi.org/10.1016/s0736-5748(03)00031-5" @default.
• W2024491864 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12711349" @default.
• W2024491864 hasPublicationYear "2003" @default.
• W2024491864 type Work @default.
• W2024491864 sameAs 2024491864 @default.
• W2024491864 citedByCount "65" @default.
• W2024491864 countsByYear W20244918642012 @default.
• W2024491864 countsByYear W20244918642013 @default.
• W2024491864 countsByYear W20244918642014 @default.
• W2024491864 countsByYear W20244918642016 @default.
• W2024491864 countsByYear W20244918642018 @default.
• W2024491864 countsByYear W20244918642019 @default.
• W2024491864 countsByYear W20244918642020 @default.
• W2024491864 countsByYear W20244918642021 @default.
• W2024491864 countsByYear W20244918642022 @default.
• W2024491864 crossrefType "journal-article" @default.
• W2024491864 hasAuthorship W2024491864A5014617287 @default.
• W2024491864 hasAuthorship W2024491864A5037422954 @default.
• W2024491864 hasAuthorship W2024491864A5045330820 @default.
• W2024491864 hasAuthorship W2024491864A5054045083 @default.
• W2024491864 hasAuthorship W2024491864A5067600290 @default.
• W2024491864 hasAuthorship W2024491864A5080614846 @default.
• W2024491864 hasConcept C126322002 @default.
• W2024491864 hasConcept C169760540 @default.
• W2024491864 hasConcept C185592680 @default.
• W2024491864 hasConcept C25498285 @default.
• W2024491864 hasConcept C2776151105 @default.
• W2024491864 hasConcept C2776925932 @default.
• W2024491864 hasConcept C2777496795 @default.
• W2024491864 hasConcept C2779134260 @default.
• W2024491864 hasConcept C2780829032 @default.
• W2024491864 hasConcept C55493867 @default.
• W2024491864 hasConcept C71924100 @default.
• W2024491864 hasConcept C86803240 @default.
• W2024491864 hasConcept C98274493 @default.
• W2024491864 hasConceptScore W2024491864C126322002 @default.
• W2024491864 hasConceptScore W2024491864C169760540 @default.
• W2024491864 hasConceptScore W2024491864C185592680 @default.
• W2024491864 hasConceptScore W2024491864C25498285 @default.
• W2024491864 hasConceptScore W2024491864C2776151105 @default.
• W2024491864 hasConceptScore W2024491864C2776925932 @default.
• W2024491864 hasConceptScore W2024491864C2777496795 @default.
• W2024491864 hasConceptScore W2024491864C2779134260 @default.
• W2024491864 hasConceptScore W2024491864C2780829032 @default.
• W2024491864 hasConceptScore W2024491864C55493867 @default.
• W2024491864 hasConceptScore W2024491864C71924100 @default.
• W2024491864 hasConceptScore W2024491864C86803240 @default.
• W2024491864 hasConceptScore W2024491864C98274493 @default.
• W2024491864 hasIssue "3" @default.
• W2024491864 hasLocation W20244918641 @default.
• W2024491864 hasLocation W20244918642 @default.
• W2024491864 hasOpenAccess W2024491864 @default.
• W2024491864 hasPrimaryLocation W20244918641 @default.
• W2024491864 hasRelatedWork W1969122285 @default.
• W2024491864 hasRelatedWork W2050697792 @default.
• W2024491864 hasRelatedWork W2124369185 @default.
• W2024491864 hasRelatedWork W2796692882 @default.
• W2024491864 hasRelatedWork W2965035470 @default.

• next