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- W2024492191 abstract "This study investigated the influence of titanium dioxide nanoparticles (n-TiO2) on the bioavailability, metabolism, and toxicity of pentachlorophenol (PCP) in fish. Zebrafish (Danio rerio) embryos or larvae (2-h post-fertilization) were exposed to PCP (0, 3, 10, and 30 μg/L) alone or in combination with n-TiO2 (0.1 mg/L) until 6 days post-fertilization. Results showed that n-TiO2 treatment alone did not induce lipid peroxidation, DNA damage, as well as the generation of reactive oxygen species (ROS) in the larvae. As compared with PCP treatment, the co-exposure of PCP and n-TiO2 enhanced the induction of ROS generation, eventually leading to lipid peroxidation and DNA damage. The nuclear factor erythroid 2-related factor 2 gene transcriptions were significantly upregulated in both PCP treatment alone and in combination with n-TiO2. Chemical analysis and histological examination showed that n-TiO2 adsorb PCP, and n-TiO2 are taken up by developing zebrafish larvae; however, PCP content was not enhanced in the presence of n-TiO2, but the metabolism of PCP to tetrachlorohydroquinone was enhanced in larvae. The results indicate that n-TiO2 enhanced the metabolism of PCP and caused oxidative damage and developmental toxicity, suggesting that NPs can influence the fate and toxicity of associated organic pollutants in the aquatic environment." @default.
- W2024492191 created "2016-06-24" @default.
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- W2024492191 date "2015-02-01" @default.
- W2024492191 modified "2023-10-13" @default.
- W2024492191 title "Effect of titanium dioxide nanoparticles on the bioavailability, metabolism, and toxicity of pentachlorophenol in zebrafish larvae" @default.
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- W2024492191 doi "https://doi.org/10.1016/j.jhazmat.2014.10.039" @default.
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