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- W2024492733 abstract "In utero cocaine exposure is a risk factor for adverse neurodevelopmental outcome. AIM: To determine whether COC and CON differ in intelligence scores at age 4 yr. STUDY DESIGN: As part of a prospective, long-term study in which we are following COC and CON of similar low socioeconomic status, individuals masked to child group status administered the WPPSI-R to children aged 48 mo. Because multiple factors may influence intelligence, the effect of primary caretaker(biologic or foster), home environment [Home Observation for Measurement of the Environment (HOME)], and social support [Social Support Scale (SSS) and Inventory of Social Support (ISS)] were also assessed.RESULTS. COC (n=55) and CON (n=51) were similar in natal status, gender, scores on Bayley Scales, and age at testing (both 48.8 mo.)(all p>0.05). COC and CON did not differ in mean Performance, Verbal, and Full Scale IQ scores (p≥0.14). However, with the exception of CON Performance IQ, all mean IQ scores were >1 S.D. below the test mean of 100(Figure). On the HOME, COC was lower in language, learning, and academic stimulation, and total score (all p<0.05). COC also differed from CON on 4 of 12 SSS items and 2 of 18 ISS items (all p<0.018). By regression analysis, Performance, Verbal, and Full Scale IQ scores were associated with total HOME score (p≤0.01), but not with COC or CON status, primary caretaker, SSS or ISS. CONCLUSION: Inner city children, COC and CON, perform poorly on intelligence testing at age 4 yrs. The home environment, while worse in COC than CON, influenced IQ scores of both. Given the young age of these children, and the significant effect of the home, measures to change poor WPPSI-R outcome must be targeted, powerful, and early. (Funded by NIDA DA-04965.)" @default.
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- W2024492733 date "1996-04-01" @default.
- W2024492733 modified "2023-09-26" @default.
- W2024492733 title "INNER CITY CHILDREN WITH IN UTERO COCAINE EXPOSURE (COC) DO NOT DIFFER FROM CONTROLS (CON) ON WECHSLER PRESCHOOL AND PRIMARY SCALE OF INTELLIGENCE-REVISED (WPPSI-R). ▴ 1592" @default.
- W2024492733 doi "https://doi.org/10.1203/00006450-199604001-01615" @default.
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