Matches in SemOpenAlex for { <https://semopenalex.org/work/W2024493076> ?p ?o ?g. }
Showing items 1 to 96 of
96
with 100 items per page.
- W2024493076 endingPage "E323" @default.
- W2024493076 startingPage "E319" @default.
- W2024493076 abstract "The purpose of this study was to assess a novel technique for quantifying in vivo muscle protein metabolism and phenylalanine transport in septic patients and normal volunteers and thereby assess the influence of sepsis on muscle protein kinetics. In patients resuscitated from sepsis, blood flow and edema may influence the extent of muscle loss. Six adult patients septic from pneumonia underwent a study protocol consisting of infusion of isotopic phenylalanine, indocyanine green dye, and sodium bromide; biopsies of skeletal muscle; and sampling from the femoral artery, vein, and interstitial fluid. Study results demonstrate a substantial net catabolism of muscle, an accelerated flux of phenylalanine, and an increased leg blood flow for septic patients compared with normal volunteers. For septic patients and normal volunteers, the rate of phenylalanine transport through the interstitium was rate limiting for the movement of phenylalanine between vasculature and muscle. Measurements demonstrate a concentration gradient of phenylalanine favoring the net efflux of amino acids from the leg in the septic patients. Despite whole body edema, the extracellular fluid volume within muscle of septic patients was similar to normal. These findings demonstrate that the extent of muscle loss in critically ill patients results from the net increase in the rate of muscle protein breakdown, which subsequently drives amino acids through the interstitial compartment down their concentration gradient. Therefore, any effective therapy to correct illness-induced muscle catabolism should be directed at altering the rates of breakdown and synthesis of muscle protein and are not likely related to tissue edema." @default.
- W2024493076 created "2016-06-24" @default.
- W2024493076 creator A5015689121 @default.
- W2024493076 creator A5060298854 @default.
- W2024493076 creator A5088819443 @default.
- W2024493076 date "2007-01-01" @default.
- W2024493076 modified "2023-09-26" @default.
- W2024493076 title "Quantification of amino acid transport through interstitial fluid: assessment of four-compartment modeling for muscle protein kinetics" @default.
- W2024493076 cites W1824736859 @default.
- W2024493076 cites W1908806204 @default.
- W2024493076 cites W1972095163 @default.
- W2024493076 cites W1986473287 @default.
- W2024493076 cites W1993356654 @default.
- W2024493076 cites W2042151555 @default.
- W2024493076 cites W2060234059 @default.
- W2024493076 cites W2062291205 @default.
- W2024493076 cites W2069199585 @default.
- W2024493076 cites W2135532864 @default.
- W2024493076 cites W2137789014 @default.
- W2024493076 cites W2138917603 @default.
- W2024493076 cites W2139656274 @default.
- W2024493076 cites W2183437665 @default.
- W2024493076 cites W2414082932 @default.
- W2024493076 doi "https://doi.org/10.1152/ajpendo.00399.2005" @default.
- W2024493076 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16954330" @default.
- W2024493076 hasPublicationYear "2007" @default.
- W2024493076 type Work @default.
- W2024493076 sameAs 2024493076 @default.
- W2024493076 citedByCount "13" @default.
- W2024493076 countsByYear W20244930762012 @default.
- W2024493076 countsByYear W20244930762013 @default.
- W2024493076 countsByYear W20244930762019 @default.
- W2024493076 crossrefType "journal-article" @default.
- W2024493076 hasAuthorship W2024493076A5015689121 @default.
- W2024493076 hasAuthorship W2024493076A5060298854 @default.
- W2024493076 hasAuthorship W2024493076A5088819443 @default.
- W2024493076 hasConcept C111368507 @default.
- W2024493076 hasConcept C126322002 @default.
- W2024493076 hasConcept C127313418 @default.
- W2024493076 hasConcept C134018914 @default.
- W2024493076 hasConcept C150489694 @default.
- W2024493076 hasConcept C185592680 @default.
- W2024493076 hasConcept C197683979 @default.
- W2024493076 hasConcept C203635412 @default.
- W2024493076 hasConcept C2777431362 @default.
- W2024493076 hasConcept C2777628635 @default.
- W2024493076 hasConcept C2778384902 @default.
- W2024493076 hasConcept C2779822359 @default.
- W2024493076 hasConcept C2779959927 @default.
- W2024493076 hasConcept C2780886150 @default.
- W2024493076 hasConcept C515207424 @default.
- W2024493076 hasConcept C55493867 @default.
- W2024493076 hasConcept C62231903 @default.
- W2024493076 hasConcept C71924100 @default.
- W2024493076 hasConcept C96942376 @default.
- W2024493076 hasConceptScore W2024493076C111368507 @default.
- W2024493076 hasConceptScore W2024493076C126322002 @default.
- W2024493076 hasConceptScore W2024493076C127313418 @default.
- W2024493076 hasConceptScore W2024493076C134018914 @default.
- W2024493076 hasConceptScore W2024493076C150489694 @default.
- W2024493076 hasConceptScore W2024493076C185592680 @default.
- W2024493076 hasConceptScore W2024493076C197683979 @default.
- W2024493076 hasConceptScore W2024493076C203635412 @default.
- W2024493076 hasConceptScore W2024493076C2777431362 @default.
- W2024493076 hasConceptScore W2024493076C2777628635 @default.
- W2024493076 hasConceptScore W2024493076C2778384902 @default.
- W2024493076 hasConceptScore W2024493076C2779822359 @default.
- W2024493076 hasConceptScore W2024493076C2779959927 @default.
- W2024493076 hasConceptScore W2024493076C2780886150 @default.
- W2024493076 hasConceptScore W2024493076C515207424 @default.
- W2024493076 hasConceptScore W2024493076C55493867 @default.
- W2024493076 hasConceptScore W2024493076C62231903 @default.
- W2024493076 hasConceptScore W2024493076C71924100 @default.
- W2024493076 hasConceptScore W2024493076C96942376 @default.
- W2024493076 hasIssue "1" @default.
- W2024493076 hasLocation W20244930761 @default.
- W2024493076 hasLocation W20244930762 @default.
- W2024493076 hasOpenAccess W2024493076 @default.
- W2024493076 hasPrimaryLocation W20244930761 @default.
- W2024493076 hasRelatedWork W1642498015 @default.
- W2024493076 hasRelatedWork W1927591950 @default.
- W2024493076 hasRelatedWork W1981229103 @default.
- W2024493076 hasRelatedWork W1992523552 @default.
- W2024493076 hasRelatedWork W2032110122 @default.
- W2024493076 hasRelatedWork W2080369210 @default.
- W2024493076 hasRelatedWork W2119527577 @default.
- W2024493076 hasRelatedWork W2139232831 @default.
- W2024493076 hasRelatedWork W2277143721 @default.
- W2024493076 hasRelatedWork W906523005 @default.
- W2024493076 hasVolume "292" @default.
- W2024493076 isParatext "false" @default.
- W2024493076 isRetracted "false" @default.
- W2024493076 magId "2024493076" @default.
- W2024493076 workType "article" @default.