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• W2024494035 abstract "Lithium transport across the cell membrane is interesting in the light of general cell physiology and because of its alteration during numerous human diseases. The mechanism of Li+ transfer has been studied mainly in erythrocytes with a slow kinetics of ion exchange and therefore under the unbalanced ion distribution. Proliferating cultured cells with a rapid ion exchange have not been used practically in study of Li+ transport. In the present paper, the kinetics of Li+ uptake and exit, as well as its balanced distribution across the plasma membrane of U937 cells, were studied at minimal external Li+ concentrations and after the whole replacement of external Na+ for Li+. It is found that a balanced Li+ distribution attained at a high rate similar to that for Na+ and Cl− and that Li+/Na+ discrimination under balanced ion distribution at 1–10 mM external Li+ stays on 3 and drops to 1 following Na, K-ATPase pump blocking by ouabain. About 80% of the total Li+ flux across the plasma membrane under the balanced Li+ distribution at 5 mM external Li+ accounts for the equivalent Li+/Li+ exchange. The majority of the Li+ flux into the cell down the electrochemical gradient is a flux through channels and its small part may account for the NC and NKCC cotransport influxes. The downhill Li+ influxes are balanced by the uphill Li+ efflux involved in Li+/Na+ exchange. The Na+ flux involved in the countertransport with the Li+ accounts for about 0.5% of the total Na+ flux across the plasma membrane. The study of Li+ transport is an important approach to understanding the mechanism of the equivalent Li+/Li+/Na+/Na+ exchange, because no blockers of this mode of ion transfer are known and it cannot be revealed by electrophysiological methods. Cells cultured in the medium where Na+ is replaced for Li+ are recommended as an object for studying cells without the Na,K-ATPase pump and with very low intracellular Na+ and K+ concentration." @default.
• W2024494035 created "2016-06-24" @default.
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• W2024494035 date "2014-01-01" @default.
• W2024494035 modified "2023-10-18" @default.
• W2024494035 title "Li/Na exchange and Li active transport in human lymphoid cells U937 cultured in lithium media" @default.
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• W2024494035 doi "https://doi.org/10.1134/s1990519x1401012x" @default.
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• W2024494035 hasPublicationYear "2014" @default.
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