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• W2024494094 abstract "The evolutionarily conserved p38 mitogen-activated protein kinase (MAPK) cascade is an integral part of the response to a variety of environmental stresses. Here we show that the Caenorhabditis elegans PMK-1 p38 MAPK pathway regulates the oxidative stress response via the CNC transcription factor SKN-1. In response to oxidative stress, PMK-1 phosphorylates SKN-1, leading to its accumulation in intestine nuclei, where SKN-1 activates transcription of gcs-1 , a phase II detoxification enzyme gene. These results delineate the C. elegans p38 MAPK signaling pathway leading to the nucleus that responds to oxidative stress." @default.
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• W2024494094 date "2005-09-15" @default.
• W2024494094 modified "2023-10-15" @default.
• W2024494094 title "The <i>C. elegans</i> p38 MAPK pathway regulates nuclear localization of the transcription factor SKN-1 in oxidative stress response" @default.
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• W2024494094 doi "https://doi.org/10.1101/gad.1324805" @default.
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