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- W2024495317 abstract "The synthesis of DNA, RNA and protein was measured in L1210 cells following treatment with 8-methoxypsoralen in combination with long wavelength ultraviolet irradiation. The results show that the DNA synthesis is strongly inhibited (approximately 95%) at 200 ng/ml reaching a minimum within 2 hours while RNA synthesis is only weakly affected at this concentration (approximately 40% inhibition). At 2 micrograms/ml the RNA synthesis is inhibited approximately 90%. Even at this concentration only a moderate effect is seen on the protein synthesis. These results strongly indicate that the phototoxic action of 8-methoxypsoralen is primarily due to inhibition of DNA synthesis." @default.
- W2024495317 created "2016-06-24" @default.
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- W2024495317 date "1983-05-01" @default.
- W2024495317 modified "2023-09-27" @default.
- W2024495317 title "Differentiated inhibition of DNA, RNA and protein synthesis in L1210 cells by 8-methoxypsoralen" @default.
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- W2024495317 doi "https://doi.org/10.1016/0006-291x(83)91712-6" @default.
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