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- W2024496075 endingPage "1331" @default.
- W2024496075 startingPage "1315" @default.
- W2024496075 abstract "Glycogen synthase kinase-3 (GSK-3) is a ubiquitously expressed kinase that has emerged as a promising drug target for several diseases, including various neurological conditions, Type 2 diabetes and cancer. For this reason, a number of drug candidates are being developed to achieve very different goals, any of which could have therapeutic value in the treatment of Alzheimer’s disease (AD). The importance of GSK-3 in so many processes, however, also suggests that issues of side effects will need to be addressed before GSK-3 inhibitors can be used in the clinic. This review discusses the role of GSK-3 in the development of AD, the various approaches that have been used to inhibit GSK-3 activity and the patents describing the use of GSK-3 inhibitors in the treatment of AD." @default.
- W2024496075 created "2016-06-24" @default.
- W2024496075 creator A5063352954 @default.
- W2024496075 date "2005-09-30" @default.
- W2024496075 modified "2023-09-24" @default.
- W2024496075 title "GSK-3 inhibitors and their potential in the treatment of Alzheimer’s disease" @default.
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- W2024496075 doi "https://doi.org/10.1517/13543776.15.10.1315" @default.
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