FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2024496321> ?p ?o ?g. }

• W2024496321 endingPage "83" @default.
• W2024496321 startingPage "74" @default.
• W2024496321 abstract "Non-enzymatic nitrite induced collagen cross-linking results in changes reminiscent of age-related damage and parallels the well-known model system, non-enzymatic glycation. We have recently observed that nitrite modification of basement membrane proteins can induce deleterious effects on overlying retinal pigment epithelial cells in studies relevant to age-related macular degeneration. The present work was undertaken in order to confirm 3-nitro-tyrosine (3-NT) as a product of the reaction and to identify the site specificity of nitration in collagen IV, a major component of basement membranes. Human collagen type IV was modified via incubation with 200 mM NaNO(2) (pH=7.38) for one week at 37(o)C. The modified protein was prepared in 2 different ways, including acid hydrolysis and trypsin digestion for site specificity determination. The samples were analyzed by LC/MS using a C(12) RP column. Site specificity was determined from tandem MS/MS data utilizing TurboSEQUEST software and the Swiss-Prot sequence database. 3-NT was detected in protein digests and acid hydrolysates of nitrite modified collagen IV. Positive identification with standard 3-NT was confirmed by identical R(t), lambda(max)=279 nm and 355 nm, and m/z=227. Analyses of tryptic digests identified four sites of tyrosine nitration, alpha1(IV)Y348, alpha1(IV)Y534, alpha2(IV)Y327, and alpha2(IV)Y1081. These sites are located in the triple-helical region of the protein and provide clues regarding potential sites for nitrite modification in collagen type IV." @default.
• W2024496321 created "2016-06-24" @default.
• W2024496321 creator A5045837490 @default.
• W2024496321 creator A5056891655 @default.
• W2024496321 creator A5063216510 @default.
• W2024496321 creator A5065058975 @default.
• W2024496321 date "2007-02-01" @default.
• W2024496321 modified "2023-10-11" @default.
• W2024496321 title "Tyrosine nitration site specificity identified by LC/MS in nitrite-modified collagen type IV" @default.
• W2024496321 cites W1557253076 @default.
• W2024496321 cites W1608544454 @default.
• W2024496321 cites W1821918060 @default.
• W2024496321 cites W1964066180 @default.
• W2024496321 cites W1968378905 @default.
• W2024496321 cites W1969545692 @default.
• W2024496321 cites W1971758358 @default.
• W2024496321 cites W1975515113 @default.
• W2024496321 cites W1981978551 @default.
• W2024496321 cites W1999827330 @default.
• W2024496321 cites W2001413102 @default.
• W2024496321 cites W2005652765 @default.
• W2024496321 cites W2007644407 @default.
• W2024496321 cites W2014102925 @default.
• W2024496321 cites W2022377100 @default.
• W2024496321 cites W2022550407 @default.
• W2024496321 cites W2024705346 @default.
• W2024496321 cites W2025295834 @default.
• W2024496321 cites W2027156358 @default.
• W2024496321 cites W2030467684 @default.
• W2024496321 cites W2032092394 @default.
• W2024496321 cites W2033446292 @default.
• W2024496321 cites W2034244905 @default.
• W2024496321 cites W2044800103 @default.
• W2024496321 cites W2051809818 @default.
• W2024496321 cites W2052276759 @default.
• W2024496321 cites W2067546080 @default.
• W2024496321 cites W2070592166 @default.
• W2024496321 cites W2073087436 @default.
• W2024496321 cites W2082369646 @default.
• W2024496321 cites W2083464653 @default.
• W2024496321 cites W2085023145 @default.
• W2024496321 cites W2087782227 @default.
• W2024496321 cites W2088551743 @default.
• W2024496321 cites W2088705888 @default.
• W2024496321 cites W2088810650 @default.
• W2024496321 cites W2090421214 @default.
• W2024496321 cites W2091954160 @default.
• W2024496321 cites W2097369125 @default.
• W2024496321 cites W2101095914 @default.
• W2024496321 cites W2113784410 @default.
• W2024496321 cites W2117386992 @default.
• W2024496321 cites W2120027916 @default.
• W2024496321 cites W2124198776 @default.
• W2024496321 cites W2125236492 @default.
• W2024496321 cites W2128022125 @default.
• W2024496321 cites W2151608564 @default.
• W2024496321 cites W2153318203 @default.
• W2024496321 cites W2158069865 @default.
• W2024496321 cites W2167886264 @default.
• W2024496321 cites W3024383408 @default.
• W2024496321 cites W3145351529 @default.
• W2024496321 cites W99379277 @default.
• W2024496321 doi "https://doi.org/10.1038/emm.2007.9" @default.
• W2024496321 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17334231" @default.
• W2024496321 hasPublicationYear "2007" @default.
• W2024496321 type Work @default.
• W2024496321 sameAs 2024496321 @default.
• W2024496321 citedByCount "17" @default.
• W2024496321 countsByYear W20244963212012 @default.
• W2024496321 countsByYear W20244963212018 @default.
• W2024496321 countsByYear W20244963212019 @default.
• W2024496321 countsByYear W20244963212020 @default.
• W2024496321 crossrefType "journal-article" @default.
• W2024496321 hasAuthorship W2024496321A5045837490 @default.
• W2024496321 hasAuthorship W2024496321A5056891655 @default.
• W2024496321 hasAuthorship W2024496321A5063216510 @default.
• W2024496321 hasAuthorship W2024496321A5065058975 @default.
• W2024496321 hasBestOaLocation W20244963211 @default.
• W2024496321 hasConcept C153911025 @default.
• W2024496321 hasConcept C178790620 @default.
• W2024496321 hasConcept C181199279 @default.
• W2024496321 hasConcept C185592680 @default.
• W2024496321 hasConcept C2775856698 @default.
• W2024496321 hasConcept C2776165026 @default.
• W2024496321 hasConcept C2776179834 @default.
• W2024496321 hasConcept C2776384668 @default.
• W2024496321 hasConcept C2780340462 @default.
• W2024496321 hasConcept C55493867 @default.
• W2024496321 hasConcept C86803240 @default.
• W2024496321 hasConceptScore W2024496321C153911025 @default.
• W2024496321 hasConceptScore W2024496321C178790620 @default.
• W2024496321 hasConceptScore W2024496321C181199279 @default.
• W2024496321 hasConceptScore W2024496321C185592680 @default.
• W2024496321 hasConceptScore W2024496321C2775856698 @default.
• W2024496321 hasConceptScore W2024496321C2776165026 @default.
• W2024496321 hasConceptScore W2024496321C2776179834 @default.
• W2024496321 hasConceptScore W2024496321C2776384668 @default.
• W2024496321 hasConceptScore W2024496321C2780340462 @default.

• next